Hmmm? Looks good to me?
$PepGen(PEPG.US$ Hey Dr @Jaguar8 i need you! Hehehe. What exactly am i missing here??? I dont see it?? ((((. PepGen Shares Data From Low-Dose Cohort Of PGN-EDO51 In Ongoing CONNECT1-EDO51 Phase 2 Clinical Trial For Treatment Of Duchenne Muscular Dystrophy; Says Was Well Tolerated, And All Patients Continued To Long-Term Extension Portion Of Trial. Dosing Of Second Cohort At 10 Mg/kg Is Ongoing
– PGN-EDO51 at 5 mg/kg was well tolerated, and all patients continued to long-term extension portion of trial. Dosing of second cohort at 10 mg/kg is ongoing –
– Four doses of PGN-EDO51 at 5 mg/kg achieved mean exon skipping levels of 2.15% after three months of dosing –
– PGN-EDO51 at 5 mg/kg showed mean muscle-adjusted dystrophin level of 1.49%, a 0.70% increase from baseline, after three months of dosing –
– PGN-EDO51 at 5 mg/kg showed mean absolute dystrophin level of 0.61%, a 0.26% increase from baseline, after three months of dosing
– PGN-EDO51 at 5 mg/kg was well tolerated, and all patients continued to long-term extension portion of trial. Dosing of second cohort at 10 mg/kg is ongoing –
– Four doses of PGN-EDO51 at 5 mg/kg achieved mean exon skipping levels of 2.15% after three months of dosing –
– PGN-EDO51 at 5 mg/kg showed mean muscle-adjusted dystrophin level of 1.49%, a 0.70% increase from baseline, after three months of dosing –
– PGN-EDO51 at 5 mg/kg showed mean absolute dystrophin level of 0.61%, a 0.26% increase from baseline, after three months of dosing
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Jaguar8 : Increase of the mean dystrophin level is ideal which happened in this case. I didn’t get what your question is though. I’ll get back to you in an hour. My PT is here
Trytosaveabit OP Jaguar8 : Kk GL! When you get back you can answer! I was asking if I missed something in the data that is bad and explains the big drop?? Because I see pretty good data so far.
Jaguar8 : All the levels are positive findings for this trial cohort.
Trytosaveabit OP Jaguar8 : Ok brother! Thank you, that’s what I thought but with the big drop right after the data was posted, I thought I was missing something! Hehehe.
Jaguar8 Trytosaveabit OP : I wonder why this dropped.
Trytosaveabit OP Jaguar8 : So now that you had a bit of time. You see why I asked. Hehehe. Yes it’s a very low volume drop. But a significant drop nonetheless on what I think is pretty bullish data.
Jaguar8 Trytosaveabit OP : Didn’t get to monitor this when you posted because of my PT. Did it rise a bit
Jaguar8 : Hmm I wonder why this dropped. It’s mean exon 51 skipping level of 2.14 falls within normal for this and considered therapeutic (2-10%).
Jaguar8 : I have a hunch. I think people took the 2%, 1.49% as not good. They didn’t look at the variables involved.
Trytosaveabit OP Jaguar8 : At the time I asked! Nope it was just down down down! Hehehe. Yeah I figured by your response that’s what was up! Did it go well? Just a yes or know out here would be sufficient for now. Hehehe
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