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Lumos Pharma Announces New Analyses of Phase 2 OraGrowtH212 Trial Presented at ENDO 2024
Lumos Pharma presented new analyses of its Phase 2 OraGrowtH212 trial at the ENDO 2024 meeting. The data reveals that oral LUM-201 significantly increased growth hormone (GH) secretion in children with moderate Pediatric Growth Hormone Deficiency (PGHD) over six months. The treatment restored GH levels to near-normal compared to healthy children, with lower GH exposure than traditional rhGH injections. This supports Lumos Pharma's plans for a Phase 3 trial. Results showed GH secretion increased from 0.19 to 0.36 μg/kg/12-hrs at 1.6 mg/kg/day dose and from 1.17 to 1.8 μg/kg/12-hrs for pulsatile GH. The data suggests a positive correlation between growth response and GH pulsatility patterns.
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