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Allakos Announces Positive Results from its Ongoing Phase 1 Trial of AK006 in Healthy Volunteers, with AK006 Demonstrating High Receptor Occupancy on Mast Cells and a Favorable Safety Profile
Allakos has announced positive results from the Phase 1 trial of AK006, a Siglec-6 monoclonal antibody being developed to treat mast cell-driven diseases. The drug demonstrated high receptor occupancy on mast cells and a favorable safety profile, with no serious adverse events. Healthy volunteers received single and multiple ascending doses up to 720 mg, achieving serum concentrations consistent with inhibitory activity shown in preclinical experiments. High levels of receptor occupancy were confirmed through skin biopsies. AK006 showed dose linear exposure and an estimated half-life of 21 days for the 720 mg IV dose. The ongoing trial also includes a cohort of patients with chronic spontaneous urticaria (CSU), with preliminary efficacy data expected by year-end 2024.
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