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Verastem Oncology Receives FDA Orphan Drug Designation for Avutometinib and Defactinib for the Treatment of Pancreatic Cancer
Verastem Oncology (Nasdaq: VSTM) has received FDA Orphan Drug Designation for avutometinib and defactinib in treating pancreatic cancer. This combination therapy, along with standard chemotherapy, showed promising results in the ongoing RAMP 205 trial for first-line metastatic pancreatic cancer. Initial interim data presented at ASCO 2024 revealed an 83% confirmed partial response rate in the dose level 1 cohort. The company plans to report updated data from the trial in Q1 2025. The Orphan Drug Designation recognizes the unmet need in pancreatic cancer treatment and offers benefits such as tax credits and potential market exclusivity.
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