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ProMIS Neurosciences Showcases Novel Vaccine Approach for Maximal Targeting of Toxic Amyloid-Beta Oligomers at the 2024 Alzheimer’s Association International Conference
ProMIS Neurosciences Inc. (Nasdaq: PMN) presented preclinical data at the 2024 Alzheimer's Association International Conference (AAIC) supporting their novel approach to optimizing an Alzheimer's disease (AD) vaccine. The company's proprietary computational platform identified four AβO-restricted conformational B cell epitopes as vaccine candidates. Vaccination with these epitopes produced strong antibody responses without measurable pro-inflammatory T cell responses against Aβ. Notably, immunization with epitope 301, the target of PMN310, alone was sufficient to produce maximal reactivity against brain AβO.
The study suggests that ProMIS' approach could potentially lead to an AD vaccine capable of inducing an effective antibody response against pathogenic Aβ. This vaccine could be administered as a preventative measure to at-risk individuals or given therapeutically to diagnosed patients to inhibit AD progression.
The study suggests that ProMIS' approach could potentially lead to an AD vaccine capable of inducing an effective antibody response against pathogenic Aβ. This vaccine could be administered as a preventative measure to at-risk individuals or given therapeutically to diagnosed patients to inhibit AD progression.
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