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TFF Pharmaceuticals Announces Positive Preclinical Data from Bivalent Universal Influenza Vaccine Candidates Manufactured by TFF Following Intranasal Immunization
TFF-dry powder HA antigen vaccine candidates induced neutralizing antibody titers in ferrets against H1 and H3 influenza strains
Ongoing funded work to assess additional influenza strains
FORT WORTH, Texas, Sept. 10, 2024 (GLOBE NEWSWIRE) -- TFF Pharmaceuticals, Inc (NASDAQ:TFFP) (the "Company" or "TFF Pharmaceuticals"), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented Thin Film Freezing (TFF) technology platform, announces positive preclinical data advancing a multivalent universal influenza vaccine manufactured by TFF to protect against seasonal and pandemic viruses. The data were produced in collaboration with Dr. Ted Ross, Global Director of Vaccine Development at Cleveland Clinic.
"These preliminary data suggest that the intranasal administration of the TFF-dry powder hemagglutinin (HA) antigen vaccine candidates is highly immunogenic and produces protective antibody titers in ferrets," said Dr. Harlan Weisman, TFF Pharmaceuticals Chief Executive Officer. "These data support continued development of a shelf-stable mucosal universal influenza vaccine that could be effective regardless of which strain emerges in any year and that could be self-administered."
The experiments conducted by Dr. Ross demonstrated that TFF-dry powder HA antigen vaccine candidates induce neutralizing antibody titers in ferrets against H1 and H3 influenza strains. No response was observed in animals vaccinated with mock vaccine.
The ferret model is the gold standard to study host immune responses and evaluate influenza vaccine and antiviral therapies due to similarities with humans. Pre-immune female ferrets received TFF-dry powder HA antigen vaccine for intranasal (IN) delivery with various mucosal adjuvants that can elicit both cellular and antibody immune responses. Mock vaccine (adjuvant only) was used as a control. Serum was collected to assess neutralizing antibody titers against influenza A viruses for H1N1 and H3N2 subtypes.
Ongoing studies will assess neutralizing antibody titers against a panel of 13 influenza A viruses isolated between 2006-2018 for H1N1 and 2012-2019 for H3N2 subtypes. After viral challenge, ferrets will be monitored daily for clinical signs and symptoms and antibody titers. These positive results will allow TFF to select an adjuvant for advanced development of a universal influenza vaccine candidate that will be delivered as a dry powder designed to protect against greater than 75% of the circulating influenza strains.
Ongoing funded work to assess additional influenza strains
FORT WORTH, Texas, Sept. 10, 2024 (GLOBE NEWSWIRE) -- TFF Pharmaceuticals, Inc (NASDAQ:TFFP) (the "Company" or "TFF Pharmaceuticals"), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented Thin Film Freezing (TFF) technology platform, announces positive preclinical data advancing a multivalent universal influenza vaccine manufactured by TFF to protect against seasonal and pandemic viruses. The data were produced in collaboration with Dr. Ted Ross, Global Director of Vaccine Development at Cleveland Clinic.
"These preliminary data suggest that the intranasal administration of the TFF-dry powder hemagglutinin (HA) antigen vaccine candidates is highly immunogenic and produces protective antibody titers in ferrets," said Dr. Harlan Weisman, TFF Pharmaceuticals Chief Executive Officer. "These data support continued development of a shelf-stable mucosal universal influenza vaccine that could be effective regardless of which strain emerges in any year and that could be self-administered."
The experiments conducted by Dr. Ross demonstrated that TFF-dry powder HA antigen vaccine candidates induce neutralizing antibody titers in ferrets against H1 and H3 influenza strains. No response was observed in animals vaccinated with mock vaccine.
The ferret model is the gold standard to study host immune responses and evaluate influenza vaccine and antiviral therapies due to similarities with humans. Pre-immune female ferrets received TFF-dry powder HA antigen vaccine for intranasal (IN) delivery with various mucosal adjuvants that can elicit both cellular and antibody immune responses. Mock vaccine (adjuvant only) was used as a control. Serum was collected to assess neutralizing antibody titers against influenza A viruses for H1N1 and H3N2 subtypes.
Ongoing studies will assess neutralizing antibody titers against a panel of 13 influenza A viruses isolated between 2006-2018 for H1N1 and 2012-2019 for H3N2 subtypes. After viral challenge, ferrets will be monitored daily for clinical signs and symptoms and antibody titers. These positive results will allow TFF to select an adjuvant for advanced development of a universal influenza vaccine candidate that will be delivered as a dry powder designed to protect against greater than 75% of the circulating influenza strains.
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