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Gain Therapeutics Presents Preclinical GT-02287 Data at Neuroscience 2024
Gain Therapeutics presented new preclinical data for GT-02287 at the Society for Neuroscience 2024 conference. The data demonstrates disease-modifying activity in both GBA-1 and idiopathic Parkinson's disease models. Key findings include:
1. Persistent rescue of motor and cognitive function after GT-02287 discontinuation
2. Improved mitochondrial function and neuroprotection in GBA1-Parkinson's disease models
3. Reduction in Tau accumulation in GBA-1 mutation and wild type cell lines
1. Persistent rescue of motor and cognitive function after GT-02287 discontinuation
2. Improved mitochondrial function and neuroprotection in GBA1-Parkinson's disease models
3. Reduction in Tau accumulation in GBA-1 mutation and wild type cell lines
The results suggest GT-02287's potential as a disease-modifying therapy for Parkinson's disease and possibly Alzheimer's disease and other tauopathies. The compound showed positive effects on mitochondrial and lysosomal health, addressing the disease cascade resulting from GCase dysfunction.
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