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Allakos Announces Phase 1 Trial Results of Subcutaneous AK006 in Healthy Volunteers
Allakos Inc. (Nasdaq: ALLK) announced results from the Phase 1 study of subcutaneous AK006 in healthy volunteers. AK006, a Siglec-6 monoclonal antibody, selectively inhibits mast cells and is being developed for mast cell-driven diseases. Key findings include:
- Subcutaneous AK006 showed approximately 77% bioavailability
- Estimated half-life of 12-22 days
- High levels of receptor occupancy in skin tissue mast cells
- 720 mg dose showed 98% receptor occupancy at day 113
- Well-tolerated with a favorable safety profile
- No serious adverse events or discontinuations due to treatment
The ongoing Phase 1 study includes a CSU arm with top-line results expected in early Q1 2025. This arm will evaluate the efficacy of 720 mg IV AK006 Q4W in antihistamine refractory CSU patients.
- Subcutaneous AK006 showed approximately 77% bioavailability
- Estimated half-life of 12-22 days
- High levels of receptor occupancy in skin tissue mast cells
- 720 mg dose showed 98% receptor occupancy at day 113
- Well-tolerated with a favorable safety profile
- No serious adverse events or discontinuations due to treatment
The ongoing Phase 1 study includes a CSU arm with top-line results expected in early Q1 2025. This arm will evaluate the efficacy of 720 mg IV AK006 Q4W in antihistamine refractory CSU patients.
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