Inozyme Pharma (INZY) announced positive interim data from its Phase 1 SEAPORT 1 trial of INZ-701 in patients with end-stage kidney disease (ESKD) undergoing hemodialysis. The trial demonstrated that INZ-701 significantly increased plasma pyrophosphate (PPi) levels in patients, with levels rising into the normal range by week 3 of the four-week dosing schedule. The drug was well-tolerated, with no drug-related treatment-emergent adverse events reported in the 11 patients who completed treatment. The company plans to initiate a registrational trial in calciphylaxis in 2025, pending regulatory alignment and funding.