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Vaccinex Reports New Findings for SIGNAL-AD Phase 1b/2 Trial of Pepinemab at Clinical Trials on Alzheimer’s Disease (CTAD) Conference in Madrid, Spain
Vaccinex (VCNX) announced new findings from its SIGNAL-AD Phase 1b/2 trial of pepinemab antibody in Alzheimer's disease. The study revealed that pepinemab treatment inhibits the expression of plasma GFAP and p-tau 217 biomarkers during Mild Cognitive Impairment (MCI). The treatment showed promising trends in slowing cognitive decline in mild dementia patients with MMSE scores of 22-26. Proteomic analysis of Cerebrospinal Fluid identified several proteins typically increasing during AD progression that were inhibited by pepinemab. Additionally, using a Brain-Chip model, pepinemab demonstrated ability to inhibit or reverse damage caused by toxic alpha synuclein aggregates, suggesting potential applications in other neurodegenerative diseases.
Vaccinex (VCNX) announced new findings from its SIGNAL-AD Phase 1b/2 trial of pepinemab antibody in Alzheimer's disease. The study revealed that pepinemab treatment inhibits the expression of plasma GFAP and p-tau 217 biomarkers during Mild Cognitive Impairment (MCI). The treatment showed promising trends in slowing cognitive decline in mild dementia patients with MMSE scores of 22-26. Proteomic analysis of Cerebrospinal Fluid identified several proteins typically increasing during AD progression that were inhibited by pepinemab. Additionally, using a Brain-Chip model, pepinemab demonstrated ability to inhibit or reverse damage caused by toxic alpha synuclein aggregates, suggesting potential applications in other neurodegenerative diseases.
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