IO Biotech announced promising Phase 2 results for its cancer vaccine IO102-IO103 combined with KEYTRUDA® in first-line metastatic lung cancer treatment. The study showed a 55% unconfirmed/48% confirmed overall response rate and 81% disease control rate in NSCLC patients. About 50% of patients showed no disease progression at 12 months, with median progression-free survival of 8.1 months. The safety profile remained consistent with previous studies, mainly showing low-grade injection site reactions. The company also presented pre-clinical data for IO112, their second T-win vaccine candidate targeting arginase 1, demonstrating anti-tumor activity.