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Arbutus and Barinthus Bio Announce New Data from the IM-PROVE II Trial Showing that the Addition of Nivolumab Increased Rates of HBsAg Loss in People with Chronic Hepatitis B
Arbutus Biopharma and Barinthus Bio announced new preliminary data from Phase 2a IM-PROVE II trial for chronic hepatitis B treatment.
The study evaluated the combination of imdusiran, VTP-300, and low-dose nivolumab.
Key findings show that 23% of participants receiving the triple combination achieved HBsAg loss by Week 48, with significantly greater mean declines in HBsAg levels (p <0.017) compared to other cohorts.
The treatment regimen was generally well-tolerated with no immune-related adverse events. The trial included 22 participants in Group C, with 13 eligible for nivolumab treatment.
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