Cybin Inc. (NYSE American:CYBN)reported groundbreaking 12-month efficacy data from its Phase 2 study of CYB003 for major depressive disorder (MDD). After two 16mg doses administered three weeks apart, 100% of participants were responsive to treatment, with 71% in remission at 12 months. The study showed a ~23-point reduction in MADRS depression scores from baseline. The 16mg dosing group demonstrated superior results compared to the 12mg group, which showed 60% response and 50% remission rates. CYB003, which received FDA Breakthrough Therapy Designation, maintained an excellent safety profile with no new adverse events reported during the 12-month follow-up.