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Lantern Pharma & Starlight Therapeutics Present LP-184 (STAR-001) Phase 1b Trial Design and Preclinical Data in Glioblastoma at Society for Neuro-Oncology (SNO) 2024 Highlighting Novel Synthetic Lethality
Lantern Pharma and its subsidiary Starlight Therapeutics presented new preclinical data and Phase 1b trial design for LP-184 (STAR-001) in glioblastoma at SNO 2024.
The data shows LP-184 combined with spironolactone increases GBM cell sensitivity up to 6-fold through ERCC3 degradation. The drug demonstrates favorable brain penetrance and effectiveness in temozolomide-resistant GBM models.
Currently in Phase 1a trials, LP-184 has shown no dose-limiting toxicities across nine patient cohorts.
The planned Phase 1b trial will evaluate LP-184 as both monotherapy and in combination with spironolactone in patients with IDH wild type GBM at first progression.
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