Relay Therapeutics (RLAY) and Elevar Therapeutics have announced an exclusive global licensing agreement for lirafugratinib, a potential best-in-class FGFR2 inhibitor for treating FGFR2-driven cholangiocarcinoma and other solid tumors. Under the agreement, Elevar receives worldwide development and commercialization rights, while Relay can earn up to $500 million in payments, including $75 million in upfront and regulatory milestones, plus up to double-digit royalties on global sales. The FDA has granted lirafugratinib breakthrough therapy and orphan drug designations, and recommended filing an NDA for FGFR2-driven CCA first, followed by a supplemental NDA for other solid tumors