$Kronos Bio (KRON.US)$ NEWS Kronos Bio to Present Clinical U...
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Kronos Bio to Present Clinical Update on Phase 1/2 Trial of KB-0742 at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
Kronos Bio announced new data from its Phase 1/2 trial of KB-0742, presented at the 2024 ASCO Annual Meeting. KB-0742 showed a manageable safety profile with no grade 3/4 neutropenia observed. Dose linear pharmacokinetics were consistent up to 80mg, and increased target engagement was noted at higher doses. The 80mg four-days-on, three-days-off cohort is currently enrolling, with an expansion cohort expected in Q3 2024. Data from 103 patients revealed manageable mild to moderate nausea and vomiting, and less than 10% discontinued due to adverse events. Anti-tumor activity was observed in case studies, and pharmacokinetic modeling predicts increased efficacy at the 80mg dose.
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