Nice to see an actual timeline

I don't plan to stick around for any Mpox products. That's one of those sad cases where it is a huge health concern, but not a good financial market. The places hardest hit by it are also where healthcare infrastructure isn't as robust.

The main hurdle to using any Mpox drug will be logistics (how to deliver it, how to store it, who will pay for it, etc). There are vaccines already available - but logistically they are impractical.

The newer vaccines are being designed to get around that "last mille problem" rather than it being an unmet need for the developed world. One of the largest hurdles is simply most vaccine products can't handle ambient temperatures and will breakdown in storage/transit if not kept cold. So a rural clinic with inconsistent electricity or lack of refrigeration can't just keep it on hand for people coming in.

Polio is a good case study for those curious about learning more. Salk developed the first vaccine in the 1950s. He intentionally left all the research in the public domain since he put the common good over the profits from a patent. It was monumental towards Polio cases all but disappearing in the US.

But it's still very much a problem in many regions of the world. And vaccine development never actually stopped - it just shifted towards reducing the burden to access. Salk's philanthropic mindset didn't live on 100% in the companies producing vaccines since then, but they were not done with ROI in mind.

Rather things like changing from an injection to a sublingual dosing to reduce skill/time needed to administered to children. It may not sound like a huge difference, but the time savings are huge when you only have as long as the liquid nitrogen you drove in with lasts to dose a whole village.

Smallpox had a similar effort. If you ever want nightmares, look at the giant circle of needles it required in the original form 😅