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Update PT $11

$Ardelyx(ARDX.US)$ has recently announced that their product, XPHOZAH (tenapanor), is ready for shipment to pharmacies. This product is intended for use as an add-on therapy for adult chronic kidney disease patients undergoing dialysis who have not responded adequately to phosphate binders or cannot tolerate any dose of phosphate binder therapy. The novel mechanism of action of XPHOZAH, which operates as a sodium hydrogen exchange 3 (NHE3) inhibitor, offers a unique alternative pathway to reduce serum phosphorus, especially for patients who are intolerant to phosphate binders.
Furthermore, the unique mechanism of action is seen as a justification for the premium pricing of XPHOZAH at $2,960/month, compared to the $1,400-2,400 monthly price range estimates for currently approved phosphate binders. Arce also considered the company’s existing commercial infrastructure, which includes a dedicated nephrology sales team of 60 reps covering about 8,000 high-prescribing nephrology health care providers. This infrastructure is predicted to contribute significantly to XPHOZAH’s early commercial traction. Lastly, Arce’s rating is also influenced by the projected net sales of XPHOZAH, which are estimated to reach $1.3M in 4Q23 for about 1.5 months of sales.
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