北美深蓝 OP : Information related to the PREVAIL trial:
The design of the PREVAIL trial refers to the lessons learned from previous CETP inhibitor CVOT failures, using stricter inclusion criteria and longer follow-up time to increase the chances of trial success.
The company expects to announce the PREVAIL trial data in 2026.
As of April 2024, the PREVAIL trial has achieved its recruitment target of 9,000 patients and extended recruitment until the end of April, with over 9,500 patients randomized.
———The purpose of designing the PREVAIL trial by the company is to validate the efficacy of obicetrapib in reducing MACE, support its marketing application, and future market promotion. Once successful, this trial can prove that obicetrapib can bring clinical benefits to ASCVD patients and make it stand out in competition with other lipid-lowering drugs.

北美深蓝 OP : Based on yesterday's trading volume (3.01 million shares), short sell ratio (8.07%), and previous trends, combined with the company's previous disclosure of information, it may be a well-planned insider trading that complies with the rules.
Intentional price manipulation before the disclosure of clinical results, followed by the result release, triggering the rules, selling off (or transferring chips to buyers), causing the stock price to drop, but the drop is within the expected range, ending the selling and starting the next trend.
During this decline, the lowest price is higher than the issuance price at the beginning of the year.
On March 28, 2024, NAP PoolCo B.V. ("PoolCo") adopted a 10b5-1 rule trading plan that could involve selling up to 2.95 million shares of the company's common stock, subject to certain price thresholds and other conditions. The purpose of this plan is to allow insiders to sell their held company stocks without violating insider trading laws. The estimated decline this time may be related to this, and the set thresholds may be related to the clinical result disclosure this time.
Here is more information on the 10b5-1 rule and the pre-arranged trading plan under this rule:
10b5-1 Rule: The 10b5-1 Rule is a rule established by the U.S. Securities and Exchange Commission (SEC) that allows company insiders (such as executives and directors) to buy and sell company stock under a preset plan, even if they later obtain inside information. The rule requires insiders to not have any insider information when formulating the trading plan, and they must submit it to the SEC before the plan takes effect.
Trading Arrangement: The 10b5-1 rule trading arrangement adopted by PoolCo allows for the sale of up to 2.95 million shares of the company's common stock under certain pre-set conditions (such as price thresholds and other conditions, but this detail is not disclosed in the company's disclosures).
Purpose: The purpose of this arrangement is to provide PoolCo with a way to sell its held company stocks without violating insider trading laws. This also helps insiders conduct stock transactions without causing speculation in the market about their stock holding intentions.
Timing: The trades under this arrangement may not begin earlier than 90 days after its adoption or two business days after the submission of the quarterly report on Form 10-Q. The expiration date of this arrangement is June 28, 2026.
PoolCo Background: PoolCo is a Dutch limited liability company representing its shareholders holding the company's common stocks, controlled by Forbion International Management B.V., and Sander Slootweg, a board member of the company, is one of the directors of Forbion International Management B.V.

北美深蓝 OP : Take a look at the largest institution holding position again. Since 2023, it has been consistently reducing its net shareholdings, with a further reduction of about 30% in Q3.

北美深蓝 OP : Finally fired the CEO.

北美深蓝 OP : After President Trump took office, canceling subsidies for electric vehicles will definitely bring negative impact to its important market - the electric vehicle industry, which is one of the bearish indicators, suggesting a decline.

北美深蓝 : Pay attention to the company's assets and liabilities ratio, focus on the interest expenses brought by net debt, the company's net cash flow, and revenue change trends. Do not act impulsively! Dismissing the CEO is also negative news, at least indicating strategic mistakes or delays that have been brought to the company, further observation is needed.