Dr. Kevin J. Tracey Receives Hans Wigzell Research Foundation's Science Prize Amounting to USD 100.000
Dr. Kevin J. Tracey Receives Hans Wigzell Research Foundation's Science Prize Amounting to USD 100.000
STOCKHOLM, Nov. 2, 2023 /PRNewswire/ -- The Hans Wigzell Research Foundation (Hans Wigzells Forskningsstiftelse) awards its annual scientific prize to Kevin J. Tracey, MD, president and CEO, at the Feinstein Institutes for Medical Research. Dr. Tracey receives the prize of USD 100.000 for his contributions to the fields of neuroscience and neuroimmunology and his pioneering discoveries in vagus nerve stimulation, the inflammatory reflex and bioelectronic medicine.
斯德哥, 2023年11月2日 /PRNewswire/ — 汉斯·威格策尔研究基金会(Hans Wigzells Forskningstiftelse)将其年度科学奖颁发给 凯文 J. Tracey,医学博士,费恩斯坦医学研究所总裁兼首席执行官。Tracey 博士获得的奖项为 100.000 美元 以表彰他在神经科学和神经免疫学领域的贡献以及他在迷走神经刺激、炎症反射和生物电子医学方面的开创性发现。
Dr. Tracey's discovery of the body's "inflammatory reflex" – a neural circuit regulating inflammatory responses, is on of his most important achievements. This unique approach combines neuroscience, immunology and electrical engineering to develop therapies and medical devices to modulate the inflammatory reflex treating conditions like rheumatoid arthritis, inflammatory bowel disease and potentially life-threatening infections.
特蕾西博士发现人体的 “炎症反射” ——一种调节炎症反应的神经回路,这是他最重要的成就之一。这种独特的方法结合了神经科学、免疫学和电气工程,开发了调节炎症反射的疗法和医疗设备,用于治疗类风湿关节炎、炎症性肠病和可能危及生命的感染等疾病。
"The prize is given to Dr. Tracey for his innovative discoveries of the mechanisms of how nerves transmit signals to stop inflammatory diseases," said Hans Wigzell, MD, PhD, on behalf of the Hans Wigzell Research Foundation. "Dr. Tracey's research is a surprising new inroad to treat inflammation using computer chips targeting nerves instead of drugs."
他说:“该奖项授予特蕾西博士,以表彰他在神经传输信号以阻止炎症性疾病的机制方面取得了创新发现。” 汉斯·威格泽尔,医学博士,代表汉斯·威格策尔研究基金会。“特蕾西博士的研究是使用针对神经的计算机芯片代替药物治疗炎症的令人惊讶的新途径。”
"I am honored and sincerely grateful to Professor Wigzell and the Foundation," said Dr. Tracey, executive vice president of research and Karches Family Distinguished Chair in Medical Research at Northwell Health, New York's largest health system. "This prize celebrates the work of outstanding teams of brilliant colleagues who dedicated years of research in the shared hope of making discoveries that improve the lives of patients needing better therapies for inflammation. Having met some of the first patients who benefited from this work, we now in turn, dedicate this prize to them."
Northwell Health研究执行副总裁兼凯奇斯家族医学研究杰出主席特蕾西博士说:“我很荣幸并衷心感谢威格泽尔教授和基金会。” 纽约的 最大的卫生系统。“该奖项旨在表彰由杰出同事组成的杰出团队所做的工作,他们投入了多年的研究,共同希望做出能够改善需要更好炎症疗法的患者的生活的发现。在遇到了一些首批从这项工作中受益的患者之后,我们现在又将这个奖项献给他们。”
Rhenman & Partners Asset Management is the initiator and founder of the research foundation.
Rhenman & Partners资产管理公司是该研究基金会的发起人和创始人。
For further information, please contact:
Hans Wigzell Research Foundation
E-mail: [email protected]
欲了解更多信息,请联系:
汉斯·威格泽尔研究基金会
电子邮件: [电子邮件保护]
About Kevin J. Tracey, MD
关于 凯文 J. Tracey,MD
Dr. Tracey is President and CEO and the Karches Family Distinguished Chair in Medical Research at the Feinstein Institutes for Medical Research. Dr. Tracey is a Professor of Neurosurgery and Molecular Medicine at the Zucker School of Medicine at Hofstra-Northwell and Executive Vice President, Research, at Northwell Health in New York.
Tracey博士是费恩斯坦医学研究所的总裁兼首席执行官兼Karches家族医学研究杰出主席。特蕾西博士是霍夫斯特拉-诺斯韦尔扎克医学院神经外科和分子医学教授,也是美国诺斯韦尔健康研究执行副总裁 纽约。
Dr. Tracey participated in the discovery of the direct inflammatory activity of tumor necrosis factor-alpha (TNF) and the direct therapeutic role of monoclonal anti-TNF antibodies. He and his colleagues also discovered the role of HMGB1 in inflammation and identified the molecular mechanisms for signal transduction by signaling through pattern recognition receptors.
Tracey博士参与发现了肿瘤坏死因子-α(TNF)的直接炎症活性以及单克隆抗肿瘤坏死因子抗体的直接治疗作用。他和他的同事还发现了 HMGB1 在炎症中的作用,并通过模式识别受体发出信号,确定了信号转导的分子机制。
His laboratory discovered the molecular and neural mechanism for the reflexive control of inflammation, now termed the inflammatory reflex. They delineated the neurophysiological mechanisms dependent upon action potentials transmitted in the vagus nerve, which regulate a T cell subset producing acetylcholine. This lymphocyte derived neurotransmitter interacts with alpha-7 nicotinic receptors expressed in macrophages and receptor-ligand signal transduction in turn inhibits cytokine release.
他的实验室发现了反身控制炎症的分子和神经机制,现在称为炎症反射。他们描述了依赖于迷走神经中传递的动作电位的神经生理机制,迷走神经调节产生乙酰胆碱的T细胞亚群。这种淋巴细胞衍生的神经递质与巨噬细胞中表达的α-7烟碱受体相互作用,而受体-配体信号转导反过来又抑制细胞因子的释放。
These discoveries led to the first clinical trials of neuromodulating devices to replace anti-inflammatory drugs and spawned a new field, termed bioelectronic medicine. This work has been highly cited in the peer-reviewed scientific literature and in other media. Numerous other clinical trials of devices to stimulate the inflammatory reflex in patients with rheumatoid arthritis, inflammatory bowel disease and other conditions are in progress.
这些发现促成了首次使用神经调节设备取代抗炎药物的临床试验,并催生了一个名为生物电子医学的新领域。这项工作在同行评审的科学文献和其他媒体中得到了高度引用。许多其他刺激类风湿关节炎、炎症性肠病和其他疾病患者炎症反射的设备的临床试验正在进行中。
His research has provided novel and basic discoveries that have been translated into clinical development and practice and his work has been published with more than 1,000 co-authors, collaborators, post-docs and students and Dr. Tracey is one of the most cited scientists in the world.
他的研究提供了新颖和基本的发现,这些发现已转化为临床开发和实践,他的著作已发表,有1,000多位合著者、合作者、博士后和学生,Tracey博士是世界上被引用次数最多的科学家之一。
Dr. Tracey received his BS in chemistry, summa cum laude, Phi Beta Kappa, from Boston College in 1979, and his MD from Boston University in 1983. He trained in neurosurgery from 1983 to 1992 at the New York Hospital-Cornell University Medical Center and was a guest investigator at the Rockefeller University before moving in 1992 to the Feinstein Institutes. He directs the Laboratory of Biomedical Science and was appointed president and CEO there in 2005.
Tracey 博士以优异成绩获得化学学士学位 Phi Beta Kappa 波士顿学院 1979 年,他的医学博士来自 波士顿大学 在 1983 年。他从 1983 年到 1992 年在纽约医院接受神经外科培训-康奈尔大学 医疗中心,曾是该中心的客座调查员 洛克菲勒大学 然后在 1992 年转到费恩斯坦研究所。他领导生物医学科学实验室,并于2005年被任命为该实验室的总裁兼首席执行官。
About Hans Wigzell, Professor of Immunology, Karolinska Institutet
关于 汉斯·威格泽尔,免疫学教授, 卡罗林斯卡学院
Former President of Karolinska Institutet, former Chairman of KI's Nobel Committee and former Director General of the Infectious Diseases Institute and National Bacteriological Laboratory. Hans is also a member of the Royal Swedish Academy of Sciences and the Royal Swedish Academy of Engineering Sciences IVA. Hans is part of the Scientific Advisory Board within the Foundation.
曾任卡罗林斯卡研究所所长、KI 诺贝尔委员会前主席、传染病研究所和国家细菌学实验室前任总干事。汉斯还是瑞典皇家科学院和瑞典皇家工程科学院(IVA)的成员。汉斯是基金会科学顾问委员会的成员。
About Hans Wigzell Research Foundation
关于汉斯·威格泽尔研究基金会
The foundation promotes its support of scientific research and education in the medical field, in particular through scholarships and other grants. It will also organize and/or support seminars and conferences. Foundation board: Olle Stenman (chairman), Dan Hoflund, Lynda Ondrasek Olofsson and Göran Nordström. The Foundation has established a Scientific Advisory Board for nominations and decisions. In addition to Hans Wigzell, the scientific advisory board consists of professors Ulf Eriksson, Mats Wahlgren and Ingemar Ernberg.
该基金会促进其对医学领域科学研究和教育的支持,特别是通过奖学金和其他补助金。它还将组织和/或支持研讨会和会议。 基金会董事会: Olle Stenman (主席), 丹·霍夫伦德, 琳达·昂德拉塞克·奥洛夫森 还有戈兰·诺德斯特龙。该基金会成立了负责提名和决策的科学顾问委员会。除此之外 汉斯·威格泽尔,科学顾问委员会由教授组成 乌尔夫·埃里克森, 马茨·沃尔格伦 和 英格玛·恩伯格。
About Rhenman & Partners Asset Management
关于雷曼律师事务所资产管理
Rhenman & Partners Asset Management AB ("Rhepa") was founded in 2008 and is a Stockholm-based asset manager with a focus on the healthcare sector. Rhepa is responsible for the portfolio of a sector fund registered in Luxembourg. The fund is managed by FundRock Management Company S.A. who has commissioned Rhepa to manage the fund's portfolio. Rhepa's experienced investment team is supported by a scientific advisory board consisting of medical experts with a global network of researchers and specialists.
Rhenman & Partners 资产管理公司(“Rhepa”)成立于2008年,是一家 斯德哥尔摩一家专注于医疗保健领域的资产管理公司。Rhepa负责注册于该行业的行业基金的投资组合 卢森堡。该基金由FundRock Management Company S.A. 管理,该公司已委托Rhepa管理该基金的投资组合。Rhepa经验丰富的投资团队由具有全球研究人员和专家网络的医学专家组成的科学顾问委员会提供支持。
The following files are available for download:
以下文件可供下载:
Press release (PDF) | |
Dr. Kevin J. Tracey |
新闻稿 (PDF) | |
凯文 J. Tracey 博士 |
SOURCE Hans Wigzells Forskningsstiftelse
来源 Hans Wigzells 研究基金会