Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our analyst ratings page.

• Guggenheim analyst Subbu Nambi initiated coverage on Twist Bioscience Corporation (NASDAQ:TWST) with a Buy rating, while announcing a price target of $53. Twist Bioscience shares gained 6.8% to close at $46.98 on Tuesday. See how other analysts view this stock.
• BMO Capital analyst Fadi Chamoun initiated coverage on Old Dominion Freight Line, Inc. (NASDAQ:ODFL) with an Outperform rating and announced a price target of $210. Old Dominion Freight Line shares rose 1.7% to settle at $172.14 on Tuesday. See how other analysts view this stock.
• Cantor Fitzgerald analyst Troy Jensen initiated coverage on Proto Labs, Inc. (NYSE:PRLB) with an Overweight rating, while announcing a price target of $44. Proto Labs shares fell 0.2% to settle at $30.32 on Tuesday. See how other analysts view this stock.
• Goldman Sachs analyst Madhu Kumar initiated coverage on Jazz Pharmaceuticals plc (NASDAQ:JAZZ) with a Buy rating and announced a price target of $169. Jazz Pharmaceuticals shares fell 1.2% to close at $104.48 on Tuesday. See how other analysts view this stock.
• Craig-Hallum analyst Jeff Van Rhee initiated coverage on Spire Global, Inc. (NYSE:SPIR) with a Buy rating, while announcing a price target of $13. Spire Global shares rose 1.1% to settle at $9.33 on Tuesday. See how other analysts view this stock.