Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our analyst ratings page.

• BMO Capital analyst Keith Tapper initiated coverage on ACADIA Pharmaceuticals Inc. (NASDAQ:ACAD) with an Outperform rating and announced a price target of $31. ACADIA Pharmaceuticals shares fell 0.6% to close at $15.50 on Wednesday. See how other analysts view this stock.
• Mizuho analyst Wei Fang initiated coverage on Grab Holdings Limited (NASDAQ:GRAB) with an Outperform rating and announced a price target of $5. Grab shares fell 0.3% to close at $3.51 on Wednesday. See how other analysts view this stock.
• Redburn Atlantic analyst Steve Chesney initiated coverage on Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) with a Buy rating and announced a price target of $545. Vertex Pharmaceuticals shares rose 0.1% to settle at $474.00 on Wednesday. See how other analysts view this stock. See how other analysts view this stock.
• Stephens & Co. analyst Mason Carrico initiated coverage on Hologic, Inc. (NASDAQ:HOLX) with an Overweight rating and announced a price target of $87. Hologic shares gained 0.9% to close at $72.27 on Wednesday. See how other analysts view this stock.
• Oppenheimer analyst Ian Zaffino initiated coverage on Kyndryl Holdings, Inc. (NYSE:KD) with an Outperform rating and announced a price target of $33. Kyndryl shares fell 1% to settle at $25.28 on Wednesday. See how other analysts view this stock.