In a regulatory filing Friday, Agenus Inc (NASDAQ:AGEN) revealed Bristol Myers Squibb & Co (NYSE:BMY) terminated a license, development, and commercialization agreement forged in 2021.
The company said that as part of a broader strategic realignment of their development pipeline, which involves other licensed products, Bristol Myers Squibb is returning AGEN1777, a TIGIT bispecific antibody, to Agenus and voluntarily terminating the BMS License Agreement, effective as of January 26, 2025.
Most recently, Roche Holdings AG's (OTC:RHHBY) TIGIT drug, tiragolumab, failed in Phase 3 SKYSCRAPER-02 study in extensive-stage small-cell lung cancer (ES-SCLC) and did not meet its co-primary endpoint of progression-free survival.
In August last year, Roche was made aware of the inadvertent disclosure of the second interim analysis of the Phase 3 SKYSCRAPER-01 study, evaluating tiragolumab plus Tecentriq (atezolizumab) versus Tecentriq alone as an initial (first-line) treatment for PD-L1-high locally advanced or metastatic non-small cell lung cancer.
In May, Merck & Co Inc (NYSE:MRK) discontinued the vibostolimab, its TIGIT drug, and pembrolizumab coformulation arm of the Phase 3 KeyVibe-010 trial.
Results from Merck's Phase 2 KeyVibe-002 trial of vibostolimab/pembrolizumab combo, with or without docetaxel for metastatic non-small cell lung cancer with progressive disease after treatment with immunotherapy and platinum-doublet chemotherapy, did not show an improvement in median PFS compared to docetaxel alone.
Bristol Myers acquired AGEN1777 in 2021 by paying Agenus $200 million in cash.
Price Action: AGEN stock is down 7.10% at $5.23 at last check Monday.
在周五的监管文件中,艾吉纳斯公司(纳斯达克股票代码:AGEN)透露,百时美施贵宝公司(纽约证券交易所:BMY)终止了两家公司在2021年签署的许可、开发和商业化协议。
该公司表示,作为其开发管道更大战略调整的一部分,百时美施贵宝正在将AGEN1777这种TIGIt二特异性抗体以及其他授权产品归还给艾吉纳斯公司,并自2025年1月26日起自愿终止BMS许可协议。
最近,罗氏控股(场外:RHHBY)的TIGIt药物Tiragolumab在大范围小细胞肺癌(ES-SCLC)的3期SKYSCRAPER-02研究中失败,并未达到其共同的无进展生存期终点。
去年8月,罗氏公司被告知了第3期SKYSCRAPER-01研究的第二次中期分析的意外披露情况,该研究评估了Tiragolumab加Tecentriq(Atezolizumab)与Tecentriq单独作为PD-L1高位限局部晚期或转移性非小细胞肺癌的初始(一线)治疗。
今年5月,默沙东公司(纽约证券交易所:MRK)停止了Vibostolimab,其TIGIt药物和Pembrolizumab在第3期KeyVibe-010试验中的联合应用。
默沙东公司的Vibostolimab / Pembrolizumab组合在去除免疫治疗和铂双药化疗后的转移性非小细胞肺癌患者中,与仅使用Docetaxel相比,中位无进展生存期没有显著提高。
百时美施贵宝于2021年以2亿美元的现金收购了AGEN1777股权。
价格走势: AGEN 股价下跌 7.10%,周一报5.23美元。