NanoViricides President Dr. Diwan Interviwed in PODD Podcast; He Explains the Revolutionary Clinical Stage Broad-Spectrum Antiviral NV-387, and the Potential of the Platform to Revolutionize Fields Beyond Virology
NanoViricides President Dr. Diwan Interviwed in PODD Podcast; He Explains the Revolutionary Clinical Stage Broad-Spectrum Antiviral NV-387, and the Potential of the Platform to Revolutionize Fields Beyond Virology
SHELTON, CT / ACCESSWIRE / October 15, 2024 / NanoViricides, Inc. (NYSE American:NNVC) (the "Company"), a clinical stage global leader in broad-spectrum antiviral nanomedicines, today announces that Anil R. Diwan, Ph.D., the Company's President and Executive Chairman, was interviewed in a podcast by the PODD Conference* host. The podcast was published on October 11, 2024, on PharmaTalkRadio.
SHELTON,康涅狄格州/ACCESSWIRE/2024年10月15日/nanoviricides公司(NYSE美国:NNVC)("公司"), 一家临床阶段的全球领先者,致力于开发广谱抗病毒纳米药物, 今日宣布公司总裁兼执行主席阿尼尔·R·迪万博士在PODD会议的主持人播客中接受了采访。该播客于2024年10月11日在PharmaTalkRadio上发布。
The interview can be viewed at the PODD website at .
您可以在PODD网站上观看该访谈。
The podcast is also available from the Company's website on the front page (nanoviricides.com).
该播客也可以在公司网站的首页(nanoviricides.com)上找到。
Dr. Diwan explained the nanoviricides technology platform and its potentially revolutionary broad-spectrum antiviral clinical drug candidate NV-387. NV-387 has demonstrated the potential of completely revolutionizing the treatment of viral infections just as penicillin revolutionized the treatment of bacterial infections, based on animal model studies.
迪万博士解释了nanoviricides技术平台及其潜在革命性广谱抗病毒临床药物候选NV-387。根据动物模型研究,NV-387已展示出完全改变病毒感染治疗的潜力,就像青霉素改变了细菌感染的治疗一样。
Dr. Diwan explained that NV-387 is highly unlikely to be escaped by viruses even as they change in the field.
迪万博士解释了NV-387极不可能被病毒规避的情况, 即使它们在实际应用中发生变化。
Dr. Diwan also talked about the multiple Phase II clinical trial strategies that the Company is currently pursuing, enabled by the broad-spectrum nature of NV-387 that opens up many antiviral indications for this drug candidate.
迪万博士还谈到了公司目前正在追求的多项II期临床试验策略, 这归功于NV-387的广谱性质, 为该药物候选开启了许多抗病毒适应症。
Dr. Diwan additionally explained how the nanoviricide platform technology can help other pharmaceutical innovators develop highly effective drugs in their own fields of interest.
迪万博士还解释了nanoviricides平台技术如何帮助其他制药创新者在他们感兴趣的领域开发高效药物。
Nanoviricide platform enables oral drug delivery of difficult to dose active pharmaceutical ingredients (API).
Encapsulation of an API in the nanoviricide nanomicelle also protects the API from bodily metabolism.
Additionally, the nanoviricide can be targeted to specific types of cells, viruses, bacteria, or other pathogenic microorganisms, by attaching receptor-based "address" for such targets to the nanoviricide. This zip-code specified drug delivery is expected to minimize side effects and toxicity of such APIs.
More importantly, many drugs show strong effectiveness in early stages of development and then get pushed out because of unfavorable pharmacokinetic and pharmacodynamic properties. Many such drugs can be rescued using the nanoviricide platform to create highly effective drugs.
nanoviricides平台实现了难于给药的原料药的口服输送。
在nanoviricides nanomicelle中对API进行封装还可以保护API不被身体代谢。
此外,nanoviricides还可以通过将基于受体的“地址”附加到nanoviricides上,将其定向到特定类型的细胞、病毒、细菌或其他病原微生物。预期这种邮政编码指定的药物递送将最大限度地减少这些API的副作用和毒性。
更重要的是,许多药物在开发的早期阶段表现出强大的疗效,然后因不利的药代动力学和药效动力学特性而被淘汰。许多这样的药物可以使用nanoviricides平台拯救,创造高度有效的药物。
*PODD Conference: Partnership Opportunities in Drug Delivery Conference
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*PODD Conference: 药物递送合作机会大会
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About NanoViricides
关于NanoViricides
NanoViricides, Inc. (the "Company") () is a clinical stage company that is creating special purpose nanomaterials for antiviral therapy. The Company's novel nanoviricide class of drug candidates and the nanoviricide technology are based on intellectual property, technology and proprietary know-how of TheraCour Pharma, Inc. The Company has a Memorandum of Understanding with TheraCour for the development of drugs based on these technologies for all antiviral infections. The MoU does not include cancer and similar diseases that may have viral origin but require different kinds of treatments.
nanoviricides公司是一家临床阶段公司,正在为抗病毒治疗创造特殊用途的纳米材料。该公司的新型纳米病毒灭活剂候选药物和纳米病毒技术基于TheraCour Pharma公司的知识产权、技术和专有技术。该公司与TheraCour签署了一份关于基于这些技术开发抗所有抗病毒感染药物的谅解备忘录。该谅解备忘录不包括可能源于病毒但需要不同治疗方式的癌症和类似疾病。
The Company has obtained broad, exclusive, sub-licensable, field licenses to drugs developed in several licensed fields from TheraCour Pharma, Inc. The Company's business model is based on licensing technology from TheraCour Pharma Inc. for specific application verticals of specific viruses, as established at its foundation in 2005.
公司已从TheraCour Pharma,Inc.获得了广泛的、独家的、可转让的领域许可,涵盖了几个许可领域内开发的药物。公司的商业模式是基于从TheraCour Pharma,Inc.获得特定病毒应用垂直领域的技术许可,自2005年成立以来已确立。
Our lead drug candidate is NV-387, a broad-spectrum antiviral drug that we plan to develop as a treatment of RSV, COVID, Long COVID, Influenza, and other respiratory viral infections, as well as MPOX/Smallpox infections. Our other advanced drug candidate is NV-HHV-1 for the treatment of Shingles. The Company cannot project an exact date for filing an IND for any of its drugs because of dependence on a number of external collaborators and consultants. The Company is currently focused on advancing NV-387 into Phase II human clinical trials.
我们的首席药物候选是NV-387,一种广谱抗病毒药物,我们计划将其开发为RSV、COVID、长期COVID、流感以及其他呼吸道病毒感染的治疗,以及MPOX/天花感染。我们的另一种先进药物候选是用于带状疱疹治疗的NV-HHV-1。公司无法预测任何药物提出IND申请的确切日期,因为依赖于许多外部合作伙伴和顾问。公司目前专注于将NV-387推进至第II期人体临床试验。
NV-CoV-2 (API NV-387) is our nanoviricide drug candidate for COVID-19 that does not encapsulate remdesivir. NV-CoV-2-R is our other drug candidate for COVID-19 that is made up of NV-387 with remdesivir encapsulated within its polymeric micelles. The Company believes that since remdesivir is already US FDA approved, our drug candidate encapsulating remdesivir is likely to be an approvable drug, if safety is comparable. Remdesivir is developed by Gilead. The Company has developed both of its own drug candidates NV-CoV-2 and NV-CoV-2-R independently.
NV-CoV-2(API NV-387)是我们的针对COVID-19的纳米病毒灭活剂候选药物,不包含瑞德西韦。NV-CoV-2-R是我们的另一种针对COVID-19的药物候选药物,由封装在其聚合物胶囊中的NV-387和瑞德西韦组成。公司认为,由于瑞德西韦已经获得美国FDA批准,我们封装瑞德西韦的药物候选者很可能是一种可批准的药物,如果安全性相当。瑞德西韦由吉利德开发。公司独立研发了两种药物候选者NV-CoV-2和NV-CoV-2-R。
The Company is also developing drugs against a number of viral diseases including oral and genital Herpes, viral diseases of the eye including EKC and herpes keratitis, H1N1 swine flu, H5N1 bird flu, seasonal Influenza, HIV, Hepatitis C, Rabies, Dengue fever, and Ebola virus, among others. NanoViricides' platform technology and programs are based on the TheraCour nanomedicine technology of TheraCour, which TheraCour licenses from AllExcel. NanoViricides holds a worldwide exclusive perpetual license to this technology for several drugs with specific targeting mechanisms in perpetuity for the treatment of the following human viral diseases: Human Immunodeficiency Virus (HIV/AIDS), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Rabies, Herpes Simplex Virus (HSV-1 and HSV-2), Varicella-Zoster Virus (VZV), Influenza and Asian Bird Flu Virus, Dengue viruses, Japanese Encephalitis virus, West Nile Virus, Ebola/Marburg viruses, and certain Coronaviruses. The Company intends to obtain a license for RSV, Poxviruses, and/or Enteroviruses if the initial research is successful. As is customary, the Company must state the risk factor that the path to typical drug development of any pharmaceutical product is extremely lengthy and requires substantial capital. As with any drug development efforts by any company, there can be no assurance at this time that any of the Company's pharmaceutical candidates would show sufficient effectiveness and safety for human clinical development. Further, there can be no assurance at this time that successful results against coronavirus in our lab will lead to successful clinical trials or a successful pharmaceutical product.
本公司还在开发针对多种病毒性疾病的药物,包括口腔和生殖器疱疹,眼部病毒性疾病,包括流行性角结膜炎和疱疹性角膜炎,H1N1甲型流感,H5N1禽流感,季节性流感,艾滋病病毒,丙型肝炎,狂犬病,登革热和埃博拉病毒等。 NanoViricides的平台技术和项目基于TheraCour的纳米药物技术,TheraCour从AllExcel获得许可。 NanoViricides拥有这项技术的全球独家永久许可证,用于针对以下多种人类病毒性疾病的具体靶向机制一直有效的特定药物治疗:人类免疫缺陷病毒(HIV / AIDS),乙型肝炎病毒(HBV),临床研究和需求繁重。与任何公司的任何药物开发努力一样,目前无法保证本公司的任何药物候选者是否显示出足够的有效性和安全性进行人类临床开发。此外,目前无法保证我们在实验室抗冠状病毒的成功结果将导致成功的临床试验或成功的药品。
This press release contains forward-looking statements that reflect the Company's current expectation regarding future events. Actual events could differ materially and substantially from those projected herein and depend on a number of factors. Certain statements in this release, and other written or oral statements made by NanoViricides, Inc. are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You should not place undue reliance on forward-looking statements since they involve known and unknown risks, uncertainties and other factors which are, in some cases, beyond the Company's control and which could, and likely will, materially affect actual results, levels of activity, performance or achievements. The Company assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future. Important factors that could cause actual results to differ materially from the company's expectations include, but are not limited to, those factors that are disclosed under the heading "Risk Factors" and elsewhere in documents filed by the company from time to time with the United States Securities and Exchange Commission and other regulatory authorities. Although it is not possible to predict or identify all such factors, they may include the following: demonstration and proof of principle in preclinical trials that a nanoviricide is safe and effective; successful development of our product candidates; our ability to seek and obtain regulatory approvals, including with respect to the indications we are seeking; the successful commercialization of our product candidates; and market acceptance of our products.
本新闻稿包含反映公司目前关于未来事件的期望的前瞻性语句。实际事件可能会大大不同于本文所述,并取决于许多因素。NanoViricides,Inc.的某些声明,以及其他书面或口头声明都是“前瞻性语句”,其含义在1933年证券法第27A节和1934年证券交易法第21E节中。由于它们涉及已知和未知的风险,不确定性和其他因素,因此您不应过分依赖前瞻性语句,并且这些因素在某些情况下超出了公司的控制并且可能会很可能,实质性地影响实际结果,活动水平,性能或成就。公司不承担公开更新或修正这些前瞻性语句的义务,出于任何原因,或更新原因实际结果可能与这些前瞻性语句中所预期的结果不同,即使将来出现新信息。导致实际结果与公司预期有所不同的重要因素包括但不限于那些文件中披露的“风险因素”和其他监管机构的公司从时间到时间提交的其他文件中披露的那些因素。虽然不可能预测或识别所有这些因素,但它们可能包括以下因素:在临床前试验中演示和原则证明纳米病毒灭活剂是安全和有效的;成功开发我们的产品候选品;我们能否寻求并获得监管批准,包括我们正在寻求的适应症;我们产品候选品的成功商业化;以及我们的产品市场接受度。
The phrases "safety", "effectiveness" and equivalent phrases as used in this press release refer to research findings including clinical trials as the customary research usage and do not indicate evaluation of safety or effectiveness by the US FDA.
本新闻稿中使用的“安全性”,“有效性”及其等效短语指研究发现,包括临床试验,作为惯常的研究用途,其不表示由美国FDA评估的安全性或有效性。
FDA refers to US Food and Drug Administration. IND application refers to "Investigational New Drug" application. cGMP refers to current Good Manufacturing Practices. CMC refers to "Chemistry, Manufacture, and Controls". CHMP refers to the Committee for Medicinal Products for Human Use, which is the European Medicines Agency's (EMA) committee responsible for human medicines. API stands for "Active Pharmaceutical Ingredient". WHO is the World Health Organization. R&D refers to Research and Development.
FDA是美国食品药品监督管理局。IND申请指的是“新药临床试验申请”。cGMP是指当前良好生产规范。CMC指的是“化学、生产和质量控制”。CHMP是指负责人类药品的欧洲药品管理局(EMA)委员会。API代表“原料药”。WHO是世界卫生组织。研发指的是研究与开发。
Contact:
NanoViricides, Inc.
info@nanoviricides.com
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NanoViricides,Inc.
info@nanoviricides.com
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ir@nanoviricides.com
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ir@nanoviricides.com
SOURCE: NanoViricides, Inc.
消息来源:NanoViricides,Inc。