The following is a summary of the ADC Therapeutics SA (ADCT) Q3 2024 Earnings Call Transcript:

Financial Performance:

• ADC Therapeutics reported a third-quarter net product revenue from ZYNLONTA of $18.0 million, a year-to-date total of $52.9 million.

• On a non-GAAP basis, the adjusted net loss for the third quarter was $29.4 million, improving from a $32.4 million loss in the same period the previous year.

• The company ended the third quarter with $274.3 million in cash and cash equivalents, which is projected to fund operations into mid-2026.

Business Progress:

• ADC Therapeutics continues to advance the commercial strategy and clinical developments for ZYNLONTA, focusing on expanding its use into earlier lines of DLBCL therapy through combination studies.

• Enrollment in the LOTIS-5 Phase III study is nearing completion, with full enrollment expected by the end of 2024 and data anticipated by the end of 2025.

• The company has discontinued the Phase Ib ADCT-601 program due to an unfavorable benefit-risk profile observed during the dose optimization and expansion phase.

Opportunities:

• ADC Therapeutics plans to expand the use of ZYNLONTA into earlier lines of therapy in DLBCL and indolent lymphomas, boosting commercial opportunities.

• The company aims to advance multiple ADC candidates in parallel and potentially partner to share development and financial risk in solid tumor treatments.

Risks:

• The discontinuation of the ADCT-601 program in solid tumors demonstrates challenges in achieving a favorable benefit-risk profile, reflecting risks associated with drug development and clinical trials.

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