On May 14, 2024, Paragon Therapeutics Announced A License Agreement Granting Spyre Therapeutics An Exclusive License To Certain Antibodies And Products Targeting Α4SS7 Integrin And Tl1A, Paragon Will Up To $22M In Milestone Payments-8K
On May 14, 2024, Paragon Therapeutics Announced A License Agreement Granting Spyre Therapeutics An Exclusive License To Certain Antibodies And Products Targeting Α4SS7 Integrin And Tl1A, Paragon Will Up To $22M In Milestone Payments-8K
2024年5月14日，Paragon Therapeutics宣佈了一項許可協議，授予Spyre Therapeutics對某些針對Α4SS7整合素和Tl1A的抗體和產品的獨家許可，Paragon將獲得高達2200萬美元的里程碑付款-8K
- Paragon will provide the Company with an exclusive license to its patents covering the related antibody, the method of use and its method of manufacture.
- Paragon will not conduct any new campaigns that generate anti-α4ß7 or anti-TL1A monospecific antibodies for at least 5 years.
- The Company will pay Paragon a low single-digit percentage royalty for single antibody products and a mid single-digit percentage royalty for products containing more than one antibody from Paragon.
- There is a royalty step-down of 1/3rd if there is no Paragon patent in effect during the royalty term.
- The royalty term ends on the later of (i) the last-to-expire licensed patent or Company patent directed to a derived antibody or (ii) 12 years from the date of first sale of a Company product.
- Agreement may be terminated on 60 days' notice by the Company; on material breach without cure; and to the extent permitted by law, on a party's insolvency or bankruptcy.
- With respect to the SPY002 License Agreement only, on a product by product basis, the Company will pay Paragon sublicensing fees of up to approximately $20 million upon the achievement of mostly commercial milestones.
- Paragon將向公司提供其專利的獨家許可，該專利涵蓋相關抗體、使用方法及其製造方法。
- Paragon在至少5年內不會開展任何產生抗α4β7或抗TL1A單特異性抗體的新活動。
- 該公司將爲單一抗體產品向Paragon支付較低的個位數百分比的特許權使用費，對於含有來自Paragon的一種以上抗體的產品，將支付中等個位數百分比的特許權使用費。
- 如果在特許權使用費期內沒有有效的Paragon專利，則特許權使用費將降低三分之一。
- 特許權使用費期限於 (i) 針對衍生抗體的最後到期的許可專利或公司專利，或 (ii) 自公司產品首次銷售之日起12年，以較低者爲準。
- 協議可以在公司提前60天發出通知後終止；如果發生重大違約而無法補救；在法律允許的範圍內，當事方破產或破產。
- 僅針對 SPY002 許可協議，在實現主要商業里程碑後，公司將逐個產品向Paragon支付高達約2,000萬美元的再許可費。