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Biogen/Eisai's Leqembi Brings Hope To Early Alzheimer's Patients Amid Logistical Challenges

Biogen/Eisai's Leqembi Brings Hope To Early Alzheimer's Patients Amid Logistical Challenges

渤健公司/愛智製藥的萊克美爲早期阿爾茨海默病患者帶來希望,儘管存在後勤挑戰。
Benzinga ·  09/09 10:12

Biogen Inc. (NASDAQ:BIIB) and Eisai Ltd's (OTC:ESALY) Alzheimer's drug Leqembi (lecanemab) is reportedly offering hope for patients in the early stages of the disease despite it not being a cure.

據報道,百健公司(納斯達克股票代碼:BIIB)和衛材有限公司(場外交易代碼:ESALY)的阿爾茨海默氏症藥物Leqembi(lecanemab)儘管無法治癒,但仍爲處於該疾病早期階段的患者帶來了希望。

For many, like Mississippi English professor Missie Meeks, the treatment is helping to slow the progression of Alzheimer's, allowing her to maintain independence in daily life.

對於許多人來說,例如密西西比英語教授米西·米克斯,這種治療有助於減緩阿爾茨海默氏症的進展,使她能夠在日常生活中保持獨立性。

Also Read: Biogen's Higher Dose Spinraza Shows To Slow Neurodegeneration Faster In Infants With Rare Neuromuscular Disorder.

另請閱讀:Biogen的更高劑量Spinraza顯示可以更快地減緩患有罕見神經肌肉疾病的嬰兒的神經變性。

Meeks, who was diagnosed with Alzheimer's ahead of her 50th birthday, has been receiving biweekly infusions of Leqembi since September 2023, giving her more time to function independently, even if the treatment hasn't eliminated her cognitive struggles.

米克斯在50歲生日之前被診斷出患有阿爾茨海默氏症,自2023年9月以來,她每兩週接受一次Leqembi注射,這使她有更多時間獨立運作,即使治療沒有消除她的認知障礙。

Leqembi, a monoclonal antibody, moderately slows memory and cognitive decline in patients with mild cognitive impairment.

Leqembi是一種單克隆抗體,可適度減緩輕度認知障礙患者的記憶力和認知能力下降。

While the drug represents a significant advancement, its rollout has faced several logistical challenges, including diagnostic bottlenecks, insurance issues, and a limited number of neurologists qualified to prescribe it.

儘管該藥物取得了重大進展,但其推出面臨着多項後勤挑戰,包括診斷瓶頸、保險問題以及有資格開處方的神經科醫生數量有限。

Patients need to undergo extensive testing, including PET and MRI scans, to confirm their eligibility, with some clinics even requiring genetic testing due to the drug's potential side effects, like brain swelling and bleeding.

患者需要接受廣泛的檢測,包括pET和MRI掃描,以確認其資格,由於該藥物的潛在副作用,例如腦腫脹和出血,一些診所甚至需要進行基因檢測。

Concerns remain over the drug's side effects and long-term benefits.

人們仍然對該藥物的副作用和長期益處感到擔憂。

Some neurologists are cautious about prescribing it, while others acknowledge the difficulties in managing its rollout, citing the steep learning curve.

一些神經科醫生對開處方持謹慎態度,而另一些神經科醫生則承認在管理其推出方面存在困難,理由是學習曲線很陡峭。

Despite these concerns, CNBC writes that the patients believe the treatment's benefits outweigh the risks.

儘管有這些擔憂,CNBC寫道,患者認爲治療的益處大於風險。

Sales of Leqembi have grown since its approval in July 2023, with Biogen reporting nearly $60 million in revenue from the drug in the first half of 2024.

自2023年7月獲得批准以來,Leqembi的銷售額有所增長,Biogen報告稱,該藥物在2024年上半年收入接近6000萬美元。

The company is working on simplifying treatment administration, including potential subcutaneous injections and extended infusion intervals, to make the drug more accessible for patients.

該公司正在努力簡化治療管理,包括可能的皮下注射和延長輸液間隔,以使患者更容易獲得該藥物。

In August, Biogen's lecanemab became the first treatment for early AD (MCI and mild dementia due to AD) that targets an underlying cause of the disease to be authorized in a European country.

8月,Biogen的lecanemab成爲歐洲國家批准的第一種針對該疾病根本原因的早期AD(MCI和由AD引起的輕度癡呆)的治療方法。

Despite the approval, the National Institute for Health and Care Excellence (NICE), in its guidance draft, said, "benefits of the new Alzheimer's drug lecanemab are too small to justify the costs."

儘管獲得批准,但美國國家健康與護理卓越研究所(NICE)在其指導草案中表示:「阿爾茨海默氏症新藥lecanemab的益處太小,不足以證明成本是合理的。」

Price Action: At last check on Monday, BIIB stock was down 0.43% to $199.71.

價格走勢:在週一的最後一次檢查中,BiIB股價下跌0.43%,至199.71美元。

Disclaimer: This content was partially produced with the help of AI tools and was reviewed and published by Benzinga editors.

免責聲明:此內容部分是在人工智能工具的幫助下製作的,並由Benzinga的編輯審閱和發佈。

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