The following is a summary of the Cellectis S.A. (CLLS) Q3 2024 Earnings Call Transcript:

Financial Performance:

• Cellectis reported significant financial progress, with $47 million triggered under the AstraZeneca joint research and collaboration agreement; $25 million upfront and $22 million from reaching development milestones.

• Cash, cash equivalents, and short-term deposits total $264 million as of September 30th, 2024, up from $156 million at the end of 2023, largely due to a $140 million investment from AstraZeneca, a $16 million disbursement from the European Investment Bank, and $27 million revenue, offset by various payments.

Business Progress:

• Cellectis announced the initiation of R&D activities for three new programs under a collaboration with AstraZeneca, focusing on different CAR T therapies and gene therapies.

• The company has decided to prioritize the development of UCART22 in BALLI-01 and UCART20x22 in NATHALI-01 studies, while de-prioritizing the development of UCART123 in AMELI-01.

• Expect to reveal data for Phase I in 2025 and maintain a focus on these strategic clinical trials.

Opportunities:

• Strategic collaboration with AstraZeneca to advance cell and gene therapy capabilities, triggering significant investment and partnership benefits.

• Focus on UCART22 and UCART20x22 trials indicates potential high-impact therapeutic options in hematological malignancies.

Risks:

• De-prioritization of UCART123 in acute myeloid leukemia (AML) due to strategic reallocation of resources, reflecting the company's need to focus on the most promising trials potentially affecting other projects.

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