The following is a summary of the Karyopharm Therapeutics Inc. (KPTI) Q3 2024 Earnings Call Transcript:

Financial Performance:

• Karyopharm announced third-quarter financial results with total revenue of $38.8 million for Q3 2024, compared to $36 million in Q3 2023.

• Net U.S. product revenue for XPOVIO in Q3 was $29.5 million.

• Gross-to-net discount rate for XPOVIO increased to 31%, driven by higher 340B utilization and Medicare rebates.

Business Progress:

• Positive updates in the SENTRY trial for myelofibrosis, with endpoint changes to absolute TSS following discussions with the FDA, aimed at enhancing the trial's outcomes.

• Continued advancement in selinexor's Phase 3 trials for multiple myeloma and solid tumors, emphasizing efforts towards establishing new standards of care.

• A notable update involves the expected top-line data release in the second half of 2025 for myelofibrosis and early 2026 for endometrial cancer.

Opportunities:

• Karyopharm's key opportunities lie in myelofibrosis and endometrial cancer, both positioned as potentially transformative markets with selinexor's unique mechanism of action. The anticipated U.S. peak annual revenue for each indication is approximately $1 billion, highlighting significant commercial potential.

Risks:

• The transition to new primary endpoints in ongoing trials could pose risks regarding regulatory approval and market acceptance if outcomes do not align with previous measures at 24 weeks.

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