The following is a summary of the Compugen Ltd. (CGEN) Q3 2024 Earnings Call Transcript:

Financial Performance:

• Compugen reported Q3 2024 revenues of approximately $17.1 million, a significant increase compared to no recorded revenue in the same period of 2023.

• Cash, cash equivalents, and investments as of September 30, 2024, stood at approximately $113.2 million, compared to $51.1 million as of December 31, 2023.

• For Q3 2024, the company recorded a net profit of $1.3 million, or $0.01 per basic and diluted share, a substantial improvement from a net loss of $9.9 million, or $0.11 per basic and diluted share in Q3 2023.

Business Progress:

• Confirmed the efficacy and safety of COM701 in platinum-resistant ovarian cancer patients, showing consistent data across studies.

• Advanced the development of COM701 for maintenance therapy in relapsed platinum-sensitive ovarian cancer.

• Received FDA IND clearance for COMP503, and initiated a Phase I study in collaboration with Gilead.

• Announced progression of AstraZeneca's Rilvegostomig through multiple Phase III trials in various cancers, potentially enhancing future revenue streams from royalties and milestone payments.

Opportunities:

• Identified a significant unmet medical need in maintenance therapy for relapsed platinum-sensitive ovarian cancer patients, presenting a less competitive landscape for COM701.

• Advanced disease in heavily pretreated patients opens possibilities for COM701 to leverage its unique pharmacodynamic effects.

Risks:

• High dependency on the successful development and regulatory approval of COM701 and other pipeline candidates, especially given the challenges in treating advanced, heavily pretreated patient populations.

• Concerns about long-term financial sustainability given the reliance on milestone payments and future funding amidst intensive R&D investments.

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