The following is a summary of the Sangamo Therapeutics, Inc. (SGMO) Q3 2024 Earnings Call Transcript:

Financial Performance:

• Sangamo Therapeutics posted a Q3 2024 earnings, highlighting significant financial and clinical achievements, including a $50 million receipt from Genentech in upfront license fees and milestone payments. This has extended their cash runway into the first quarter of 2025.

• They expect significant potential financial inflows from the Fabry disease program partnership and Pfizer's hemophilia A milestones which could provide up to $220 million over the next two years.

Business Progress:

• Transitioned from a Phase I/II company to a pre-BLA company with major advancements in regulatory pathways, particularly in their Fabry disease program.

• Established a new neurology epigenetic regulation and capsid delivery license agreement with Genentech.

• Filed their first ever IND application for a neurology indication, planning to initiate clinical trials in 2025.

• Advancing towards two potential BLA submissions in 2025, leveraging key science and technology.

Opportunities:

• The new regulatory pathway for accelerated approval in the Fabry disease program reduces time to market by approximately three years.

• Potential financial gains from strategic collaborations, particularly with Pfizer and Genentech, underpinning Sangamo's financial strategy.

• Business development discussions with potential collaborators for licensing the intravenous capsid technology.

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