The following is a summary of the Omeros Corporation (OMER) Q3 2024 Earnings Call Transcript:

Financial Performance:

• Omeros Corporation reported a net loss of $32.2 million, or $0.56 per share for Q3 2024, compared to a net loss of $56 million, or $0.97 per share in Q2 2024.

• Cash and investments totaled $123.2 million as of September 30, 2024, reflecting a decrease of $35.8 million from June 30, 2024.

Business Progress:

• Significant progress in the narsoplimab development program, with anticipated resubmission of the biologics license application.

• Advancements in zaltenibart Phase 3 clinical trials for treating paroxysmal nocturnal hemoglobinuria (PNH).

• Preparation for commercialization of zaltenibart, targeting a large market opportunity with high unmet need.

Opportunities:

• Expansion of OMIDRIA sales in the U.S. and expected commencement in ex-U.S. markets.

• Potential market entry for zaltenibart in multiple rare disease indications and significant market size ($3.9 billion in 2023, projected over $10 billion by 2032).

Risks:

• Commercial success of narsoplimab and zaltenibart weighed by regulatory approval processes and achievement of clinical endpoints.

• Financial sustainability challenged by significant quarterly losses and declining cash reserves.

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