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NewAmsterdam Pharma Presents Additional Data From Phase 3 BROOKLYN Clinical Trial Evaluating Obicetrapib In Patients With Heterozygous Familial Hypercholesterolemia At AHA Scientific Sessions 2024; Met Primary Endpoint With LDL-C Mean Reduction Versus...

NewAmsterdam Pharma Presents Additional Data From Phase 3 BROOKLYN Clinical Trial Evaluating Obicetrapib In Patients With Heterozygous Familial Hypercholesterolemia At AHA Scientific Sessions 2024; Met Primary Endpoint With LDL-C Mean Reduction Versus...

NewAmsterdam Pharma向2024年AHA科學會議展示了第3期BROOKLYN臨床試驗中有關Obicetrapib在具有雜閤家族性高膽固醇血癥患者中的額外數據;與安慰劑相比,Met主要終點,LDL-C均值降低
Benzinga ·  11/19 04:21

NewAmsterdam Pharma Presents Additional Data From Phase 3 BROOKLYN Clinical Trial Evaluating Obicetrapib In Patients With Heterozygous Familial Hypercholesterolemia At AHA Scientific Sessions 2024; Met Primary Endpoint With LDL-C Mean Reduction Versus Placebo Of 36.3% At Day 84 And 41.5% At Day 365

NewAmsterdam Pharma在2024年AHA科學會議上公佈了布魯克林三期臨床試驗的更多數據,該試驗評估了雜合子家族性高膽固醇血癥患者的Obicetrapib患者;在第84天與安慰劑相比,LDL-C平均降幅爲36.3%,在第365天達到41.5%

– Met primary endpoint with LDL-C mean reduction versus placebo of 36.3% at day 84 and 41.5% at day 365 –

— 達到主要終點,與安慰劑相比,低密度脂蛋白C的平均降幅在第84天爲36.3%,在第365天爲41.5%—

– Lp(a) mean reduction versus placebo of 45.9% at day 84 and 54.3% at day 365 –

— Lp(a)相對於安慰劑的平均降幅在第84天爲45.9%,在第365天爲54.3%—

– Total LDL-P mean reduction versus placebo of 52.5% at day 180, with small LDL-P reduction of 102.4% –

— 第 180 天與安慰劑相比,總低密度脂蛋白平均降低 52.5%,低密度脂蛋白小幅降低 102.4% —

– Safety results comparable to placebo

— 安全結果與安慰劑相當 —

NAARDEN, the Netherlands and MIAMI, Nov. 18, 2024 (GLOBE NEWSWIRE) -- NewAmsterdam Pharma Company N.V. (NASDAQ:NAMS), a late-stage, clinical biopharmaceutical company developing oral, non-statin medicines for patients at risk of cardiovascular disease ("CVD") with elevated low-density lipoprotein cholesterol ("LDL-C"), for whom existing therapies are not sufficiently effective or well-tolerated, today announced additional results from the Company's Phase 3 BROOKLYN clinical trial (NCT05425745) evaluating obicetrapib in adult patients with heterozygous familial hypercholesterolemia ("HeFH"), whose LDL-C is not adequately controlled, despite being on maximally tolerated lipid-lowering therapy. The data were presented today in an oral late-breaker presentation at the American Heart Association (AHA) Scientific Sessions.

荷蘭納爾登和邁阿密,2024年11月18日(GLOBE NEWSWIRE)——新阿姆斯特丹製藥公司(納斯達克股票代碼:NAMS)是一家處於後期階段的臨床生物製藥公司,爲有心血管疾病(「CVD」)風險的低密度脂蛋白膽固醇(「LDL-C」)患者開發口服非他汀類藥物,現有療法對這些患者不夠有效或耐受性不佳,今天公佈了該公司在布魯克林開展的三期臨床試驗(NCT05425745)的更多結果,該試驗評估了奧比曲匹在雜合子家族性成年患者中的應用高膽固醇血癥(「HeFH」),儘管正在接受最大耐受性的降脂療法,但其低密度脂蛋白仍未得到充分控制。這些數據今天在美國心臟協會(AHA)科學會議的最新口頭演講中公佈。

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