U.S. stocks traded lower toward the end of trading, with the Dow Jones index falling by more than 100 points on Wednesday.

The Dow traded down 0.27% to 43,153.13 while the NASDAQ fell 0.88% to 18,820.86. The S&P 500 also fell, dropping, 0.63% to 5,879.70.

Leading and Lagging Sectors
Health care shares rose by 0.7% on Wednesday.

In trading on Wednesday, consumer discretionary shares fell by 1.2%.

Top Headline

The EIA said crude oil inventories in the U.S. increased by 0.545 million barrels in the week ended Nov. 15, compared to market estimates of a 0.4 million gain.

Equities Trading UP

• Quantum-Si incorporated (NASDAQ:QSI) shares shot up 120% to $1.3941 after the company announced a distribution agreement with Avantor for next-generation protein sequencing portfolios for researchers.
• Shares of Williams-Sonoma, Inc. (NYSE:WSM) got a boost, surging 28% to $175.78 after the company reported better-than-expected third-quarter financial results.
• Forte Biosciences, Inc. (NASDAQ:FBRX) shares were also up, gaining 124% to $12.57 after the company secured $53 million in oversubscribed private placement to advance FB102 clinical programs across autoimmune indications, with key data readouts expected in 2025.

Equities Trading DOWN

• X3 Holdings Co., Ltd. (NASDAQ:XTKG) shares dropped 38% to $1.0299. The company announced a 1-for-20 reverse stock split.
• Shares of PainReform Ltd. (NASDAQ:PRFX) were down 27% to $1.0299 after the company announced initial topline data for PRF-110 Phase 3 clinical trial.
• Volato Group, Inc. (NYSE:SOAR) was down, falling 24% to $0.3580. Volato reported $40.3 million in revenue and confirmed NYSE acceptance of compliance plan in third quarter 10-Q.

Commodities
In commodity news, oil traded down 0.4% to $69.10 while gold traded up 0.9% at $2,655.40.

Silver traded down 0.4% to $31.130 on Wednesday, while copper rose 0.3% to $4.1560.

Euro zone

European shares closed lower today. The eurozone's STOXX 600 fell 0.02%, Germany's DAX declined 0.29% and France's CAC 40 fell 0.43%. Spain's IBEX 35 Index rose 0.01%, while London's FTSE 100 fell 0.17%.

Construction output in the Eurozone fell by 1.6% year-over-year in September compared to a 2.5% decline in the previous month. Producer prices in Germany fell by 1.1% year-over-year in October.

UK's producer prices declined by 0.8% year-over-year in October versus a revised 0.6% fall in September. Annual inflation rate in the UK rose to 2.3% in October from 1.7% in September.

Asia Pacific Markets

Asian markets closed mostly higher on Wednesday, with Japan's Nikkei 225 falling 0.16%, Hong Kong's Hang Seng Index gaining 0.21% and China's Shanghai Composite Index gaining 0.66%.

Japan's trade deficit shrank to JPY 461.25 billion in October compared to JPY 702.86 in the year-ago month.

Economics

• Mortgage applications in the U.S. rose 1.7% from the previous week in the week ending Nov. 15, compared to a 0.5% gain in the prior period.
• The EIA said crude oil inventories in the U.S. increased by 0.545 million barrels in the week ended Nov. 15, compared to market estimates of a 0.4 million gain.

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