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BullFrog AI's Collaboration With Lieber Institute for Brain Development Yields Potentially Groundbreaking Biological Stratification of Brain Expression Data

BullFrog AI's Collaboration With Lieber Institute for Brain Development Yields Potentially Groundbreaking Biological Stratification of Brain Expression Data

BullFrog AI 與利伯大腦發育研究所的合作有可能對大腦表達數據進行突破性的生物分層
GlobeNewswire ·  01/17 07:00

GAITHERSBURG, Md., Jan. 17, 2024 (GLOBE NEWSWIRE) -- BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) ("BullFrog AI" or the "Company"), a technology-enabled drug development company using artificial intelligence (AI) and machine learning to enable the successful development of pharmaceuticals and biologics, today announced early results from its collaboration with the Lieber Institute for Brain Development (LIBD) that could revolutionize the understanding and treatment of psychiatric disorders. The early findings from this global strategic partnership have successfully stratified brain expression data, offering what may turn out to be unprecedented insights into psychiatric conditions.

馬里蘭州蓋瑟斯堡,2024年1月17日(GLOBE NEWSWIRE)——BullFrog AI Holdings, Inc.(納斯達克股票代碼:BFRG;BFRGW)(“BullFrog AI” 或 “公司”)是一家利用人工智能(AI)和機器學習實現藥物和生物製劑成功開發的技術型藥物開發公司,今天公佈了與利伯大腦研究所合作的初步成果開發(LIBD)可能會徹底改變對精神疾病的理解和治療。這一全球戰略伙伴關係的早期發現成功地對大腦表達數據進行了分層,爲精神疾病提供了前所未有的見解。

"This collaboration marks a pivotal moment in psychiatric research," said Vin Singh, CEO of BullFrog AI. "By employing our bfLEAP platform on LIBD's unrivaled brain data, we've gained invaluable ground into unraveling the biological underpinnings of psychiatric disorders. These preliminary findings have the potential to not only deepen our understanding but also pave the way for developing more targeted and effective treatments that set the stage for us to seek out revenue-generating strategic partnerships with pharmaceutical companies."

BullFrog AI首席執行官文·辛格說:“這次合作標誌着精神病學研究的關鍵時刻。”“通過在LIBD無與倫比的大腦數據上使用我們的bFleap平台,我們在揭示精神疾病的生物學基礎方面取得了寶貴的基礎。這些初步發現不僅有可能加深我們的理解,而且有可能爲開發更具針對性和更有效的治療方法鋪平道路,爲我們尋求與製藥公司建立創收戰略合作伙伴關係奠定基礎。”

The proprietary data from LIBD included gene expression data from over 2,800 brain samples encompassing schizophrenia, bipolar disorder, major depressive disorder, and non-psychiatric control brains. Utilizing graph analytics, BullFrog AI and LIBD have, for the first time, clustered subjects based solely on their biological data, independent of their behavioral diagnoses. This innovative approach has yielded promising insights, highlighting distinct differences and similarities in biological pathways across various brain disorders. Moreover, it has revealed biological subtypes within individual disorders, offering a nuanced understanding that could lead to personalized treatment strategies.

來自LIBD的專有數據包括來自2,800多個大腦樣本的基因表達數據,包括精神分裂症、躁鬱症、重度抑鬱症和非精神控制大腦。利用圖表分析,BullFrog AI和LIBD首次僅根據受試者的生物學數據對受試者進行聚類,而與其行爲診斷無關。這種創新的方法產生了令人鼓舞的見解,突顯了各種腦部疾病的生物通路的明顯差異和相似之處。此外,它還揭示了個體疾病中的生物亞型,提供了細緻入微的理解,可以制定個性化的治療策略。

Daniel R. Weinberger, M.D., Director and CEO of LIBD, added, "Our collaboration with BullFrog AI has enabled us to apply cutting-edge AI technologies to our extensive brain data. The preliminary results are provocative and offer novel insights at the gene level that may only be discoverable using these novel AI technologies, offering a new lens through which we can view and potentially treat brain disorders. This is an important first step towards personalized medicine in psychiatry."

LIBD董事兼首席執行官Daniel R. Weinberger醫學博士補充說:“我們與BullFrog AI的合作使我們能夠將尖端的人工智能技術應用於大量的大腦數據。初步結果具有挑釁性,在基因層面提供了新的見解,只有使用這些新的人工智能技術才能發現這些見解,爲我們提供了一個新的視角,我們可以通過它來觀察並有可能治療腦部疾病。這是邁向精神病學個性化醫療的重要第一步。”

The market opportunity for new treatments in psychiatric disorders is vast and underserved. With increasing global awareness and demand for mental health solutions, this breakthrough presents a potential paradigm shift in treatment approaches. By identifying possible biological subtypes within disorders, BullFrog AI and LIBD are not only advancing scientific understanding but also opening doors to novel therapeutic pathways and personalized treatment strategies.

精神疾病新療法的市場機會巨大且服務不足。隨着全球對心理健康解決方案的認識和需求的提高,這一突破爲治療方法帶來了潛在的模式轉變。通過識別疾病中可能的生物亞型,BullFrog AI和LIBD不僅促進了科學理解,而且爲新的治療途徑和個性化治療策略打開了大門。

The agreement between the organizations, announced in September 2023, granted BullFrog AI exclusive access to LIBD's brain data, with the potential to commercialize products or services derived from the collaboration. The partnership represents a unique synergy between AI-driven analysis and world-class neuropsychiatric research, setting a new standard in the pursuit of effective treatments for brain disorders.

這些組織於2023年9月宣佈的協議授予BullFrog AI獨家訪問LIBD大腦數據的權限,有可能將合作產生的產品或服務商業化。該合作伙伴關係代表了人工智能驅動的分析與世界一流的神經精神病學研究之間的獨特協同作用,爲尋求腦部疾病的有效治療樹立了新的標準。

About the Lieber Institute for Brain Development (LIBD)

關於利伯大腦發育研究所(LIBD)

The mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of basic genetic and molecular mechanisms of schizophrenia and related developmental brain disorders into clinical advances that change the lives of affected individuals. LIBD is an independent, not-for-profit 501(c)(3) organization and a Maryland tax-exempt medical research institute. The Lieber Institute's brain repository of more than 4,000 human brains is the largest collection of postmortem brains for the study of neuropsychiatric disorders in the world.

利伯大腦發育研究所和馬爾茨研究實驗室的使命是將對精神分裂症和相關發育性腦部疾病的基本遺傳和分子機制的理解轉化爲改變患者生活的臨床進展。LIBD是一個獨立的非營利性501(c)(3)組織,也是馬里蘭州的一家免稅醫學研究機構。利伯研究所的大腦存儲庫擁有4,000多個人類大腦,是世界上用於神經精神疾病研究的最大驗屍大腦庫。

About BullFrog AI

BullFrog AI

BullFrog AI is a technology-enabled drug development company using Artificial Intelligence and machine learning to enable the successful development of pharmaceuticals and biologics. Through its collaborations with leading research institutions, BullFrog AI is at the forefront of AI-driven drug development using its proprietary bfLEAP artificial intelligence platform to create and analyze networks of biological, clinical, and real-world data spanning from early discovery to late-stage clinical trials. BullFrog AI is deploying bfLEAP for use at several critical stages of development with the intention of streamlining data analytics in therapeutics development, decreasing the overall development costs by decreasing failure rates for new therapeutics.

BullFrog AI 是一家以技術爲導向的藥物開發公司,使用人工智能和機器學習來實現藥物和生物製劑的成功開發。通過與領先研究機構的合作,BullFrog AI處於人工智能驅動的藥物開發的最前沿,使用其專有的bFleap人工智能平台來創建和分析從早期發現到後期臨床試驗的生物、臨床和現實世界數據網絡。BullFrog AI正在部署bFleap,用於開發的幾個關鍵階段,目的是簡化療法開發中的數據分析,通過降低新療法的失敗率來降低總體開發成本。

For more information visit BullFrog AI at:

欲了解更多信息,請訪問 BullFrog AI,網址爲:

Website:

網站:

LinkedIn:

領英:

Safe Harbor Statement

安全港聲明

This press release contains forward-looking statements. We base these forward-looking statements on our expectations and projections about future events, which we derive from the information currently available to us. Such forward-looking statements relate to future events or our future performance, including: our financial performance and projections; our growth in revenue and earnings; and our business prospects and opportunities. You can identify forward-looking statements by those that are not historical in nature, particularly those that use terminology such as "may," "should," "expects," "anticipates," "contemplates," "estimates," "believes," "plans," "projected," "predicts," "potential," or "hopes" or the negative of these or similar terms. In evaluating these forward-looking statements, you should consider various factors, including: our ability to change the direction of the Company; our ability to keep pace with new technology and changing market needs; and the competitive environment of our business. These and other factors may cause our actual results to differ materially from any forward-looking statement. Forward-looking statements are only predictions. The forward-looking events discussed in this press release and other statements made from time to time by us or our representatives, may not occur, and actual events and results may differ materially and are subject to risks, uncertainties, and assumptions about us. We are not obligated to publicly update or revise any forward-looking statement, whether as a result of uncertainties and assumptions, the forward-looking events discussed in this press release and other statements made from time to time by us or our representatives might not occur.

本新聞稿包含前瞻性陳述。這些前瞻性陳述是基於我們對未來事件的預期和預測,這些預期和預測是我們從目前獲得的信息中得出的。此類前瞻性陳述與未來事件或我們的未來業績有關,包括:我們的財務業績和預測;我們的收入和收益增長;以及我們的業務前景和機會。您可以通過非歷史性質的前瞻性陳述來識別前瞻性陳述,尤其是那些使用諸如 “可能”、“應該”、“期望”、“預期”、“考慮”、“估計”、“相信”、“計劃”、“預測”、“潛在” 或 “希望” 等術語或這些或類似術語的否定詞的陳述。在評估這些前瞻性陳述時,您應考慮各種因素,包括:我們改變公司方向的能力;我們跟上新技術和不斷變化的市場需求的能力;以及我們業務的競爭環境。這些因素和其他因素可能導致我們的實際業績與任何前瞻性陳述存在重大差異。前瞻性陳述只是預測。本新聞稿中討論的前瞻性事件以及我們或我們的代表不時發表的其他聲明可能不會發生,實際事件和結果可能存在重大差異,並受風險、不確定性和對我們的假設的影響。我們沒有義務公開更新或修改任何前瞻性陳述,無論是由於不確定性和假設,本新聞稿中討論的前瞻性事件以及我們或我們的代表不時發表的其他聲明都可能不會發生。

Contact:

聯繫人:

Investors
Dave Gentry
RedChip Companies, Inc.
BFRG@redchip.com
800-733-2447

投資者
戴夫·金特里
RedChip 公司有限公司
BFRG@redchip.com
800-733-2447

SOURCE: BullFrog AI Holdings, Inc.

資料來源:BullFrog 人工智能控股公司


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