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Theralase(R) Granted Canadian Cancer Vaccine Patent

Theralase(R) Granted Canadian Cancer Vaccine Patent

Theralase (R) 获得加拿大癌症疫苗专利
Accesswire ·  04/05 07:00

TORONTO, ON / ACCESSWIRE / April 5, 2024 / Theralase Technologies Inc. ("Theralase" or the "Company") (TSXV:TLT)(OTCQB:TLTFF), a clinical stage pharmaceutical company dedicated to the research and development of light and/or radiation activated Photo Dynamic Compounds ("PDCs") for the safe and effective destruction of various cancers, bacteria and viruses, has been granted a Canadian patent for a new cancer vaccine.

安大略省多伦多/ACCESSWIRE /2024年4月5日/Theralase Technologies Inc.(“Theralase” 或 “公司”)(多伦多证券交易所股票代码:TLT)(OTCQB: TLTFF)是一家临床阶段制药公司,致力于研究和开发用于安全有效销毁各种癌症、细菌和病毒的光和/或辐射活化光动力化合物(“PDC”),已获得加拿大专利一种新的癌症疫苗。

The recently issued patent is titled, "Vaccine Containing Cancer Cells Inactivated by Photodynamic Treatment with Metal-Based Coordination Complexes and Immunotherapy Method Using Same".

最近发布的专利的标题是,”含有癌细胞的疫苗通过金属基配位复合物的光动力学处理和使用该复合物的免疫治疗方法“。

A US patent protecting the same technology was previously issued in October 2022. A European Union patent is currently pending.

保护相同技术的美国专利此前已于2022年10月发布。一项欧盟专利目前正在申请中。

The patent protects Theralase PDC technology in the treatment of a patient with a cancer vaccine; specifically, programmed to destroy their cancer.

该专利保护了使用癌症疫苗治疗患者的Theralase PDC技术;具体而言,该技术旨在消灭他们的癌症。

This is fundamentally accomplished by obtaining a sample of their cancer and treating it extracorporeally with a Theralase PDC and then activating the PDC with either light or radiation. This inactivated cancer is then injected back into the patient intravenously, programming the patient's immune system to recognize, attack and destroy the particular cancer of interest.

这基本上是通过获取他们的癌症样本并使用Theralase PDC进行体外治疗,然后用光或辐射激活PDC来实现的。然后,通过静脉注射将这种灭活的癌症注射回患者体内,对患者的免疫系统进行编程,以识别、攻击和摧毁感兴趣的特定癌症。

Theralase's pipeline includes: a Phase II registration clinical study for bladder cancer expected to be completed in 2026, plans to launch a Phase Ib clinical study for both brain cancer and lung cancer in 2024, pending completion of a toxicology analysis, and now after the issuance of a Canadian and US patent on a cancer vaccine, the ability to treat various "liquid cancers"; such as leukemia, lymphoma and myeloma.

Theralase的产品线包括:一项预计于2026年完成的膀胱癌二期注册临床研究,计划在2024年启动一项针对脑癌和肺癌的Ib期临床研究,等待毒理学分析的完成,以及在加拿大和美国的癌症疫苗专利发布之后,还包括治疗各种 “液体癌” 的能力;例如白血病、淋巴瘤和骨髓瘤。

Dr. Arkady Mandel, MD, PhD, DSc, Chief Scientific Officer of Theralase, inventor of the patent stated, "The issuance of an additional patent for our cancer vaccine technology represents a significant opportunity for patients diagnosed with blood-related cancers, which are difficult, if not impossible, to treat. Our primary focus has been on the research and development of technology to destroy solid-core tumours, such as bladder, brain and lung cancers; however, this new patent allows the Company the opportunity to explore the treatment of various liquid cancers."

该专利的发明者Theralase首席科学官医学博士、博士、博士学位Arkady Mandel博士表示:“我们的癌症疫苗技术额外专利的签发对于被诊断患有血液相关癌症的患者来说是一个重要机会,这些癌症很难甚至不可能治疗。我们的主要重点是研究和开发消灭膀胱癌、脑癌和肺癌等固体核心肿瘤的技术;但是,这项新专利使公司有机会探索各种液体癌的治疗方法。”

Roger DuMoulin-White, President and Chief Executive Officer of Theralase stated, "The possibilities and opportunities of our PDC technology continue to grow at a rapid pace. The Company plans to become properly financed this year through various equity and debt instruments to allow the Company the opportunity to commence new clinical studies focused on the destruction of both solid-core and liquid cancers. I am excited about the opportunities available to the Company, as a result of these new patents, as it significantly increases the opportunity for our PDC technology to treat patients inflicted with a wide range of cancers."

Theralase总裁兼首席执行官罗杰·杜穆林-怀特表示:“我们的PDC技术的可能性和机遇继续快速增长。该公司计划今年通过各种股权和债务工具获得适当的融资,使公司有机会开始新的临床研究,重点是摧毁固体癌和液体癌。我对公司因这些新专利而获得的机会感到兴奋,因为这极大地增加了我们的PDC技术治疗患有各种癌症的患者的机会。”

About Leukemia:

关于白血病:

Leukemia is a cancer that starts in the stem cells of blood. As the stem cells of the blood develop, they become blast cells (blasts), which are immature blood cells. In leukemia, there is an overproduction of blast cells. These blast cells develop abnormally and don't develop into mature blood cells. Over time, the blast cells crowd out normal blood cells so that they can't do their jobs.

白血病是一种起源于血液干细胞的癌症。随着血液中干细胞的发育,它们会变成爆炸细胞(blasts),即未成熟的血细胞。在白血病中,母细胞会过度产生。这些爆炸细胞发育异常,不会发育成成熟的血细胞。随着时间的推移,爆炸细胞会挤出正常的血细胞,因此它们无法发挥作用。

Leukemia is the 11th most common cancer in the United States. As of 2019, more than 470,000 Americans have a history of leukemia. It was estimated that about 60,000 people would be diagnosed with leukemia in 2022. The five-year relative survival rate of leukemia is 65.7%.

白血病是 11第四 美国最常见的癌症。截至2019年,超过47万美国人有白血病史。据估计,到2022年,约有6万人将被诊断出患有白血病。白血病的五年相对存活率为65.7%。

About Lymphoma:

关于淋巴瘤:

Lymphoma is a type of cancer that occurs due to the malignant transformation of the lymphocytes (infection fighting cells of the immune system). The most common category of lymphoma, Non-Hodgkin Lymphoma ("NHL") is the 7th most common cancer in the United States. In 2024, the American Cancer Society's estimates 80,620 people (44,590 males and 36,030 females) will be diagnosed with NHL. The five-year relative survival rate of lymphoma is 72%.

淋巴瘤是一种由于淋巴细胞(免疫系统的抗感染细胞)的恶性转化而发生的癌症。淋巴瘤最常见的类别,非霍奇金淋巴瘤(“NHL”)是 7第四 美国最常见的癌症。据美国癌症协会估计,到2024年,将有80,620人(44,590名男性和36,030名女性)被诊断出患有NHL。淋巴瘤的五年相对存活率为72%。

About Myeloma:

关于骨髓瘤:

Myeloma, also known as multiple myeloma, is a type of blood cancer that develops from plasma cells in the bone marrow. Myeloma is the 14th most common type of cancer. In 2023, an estimated 35,730 adults in the United States will be diagnosed with multiple myeloma. The overall 5-year survival rate for people with multiple myeloma in the United States is 55%.

骨髓瘤,也称为多发性骨髓瘤,是一种由骨髓中的浆细胞发育而成的血液癌。骨髓瘤是 14第四 最常见的癌症类型。2023年,美国估计有35,730名成年人将被诊断出患有多发性骨髓瘤。在美国,多发性骨髓瘤患者的总5年存活率为55%。

About RuvidarTM:

关于 RuvidarTM:

RuvidarTM is a peer-reviewed, patented PDC currently under investigation in a Phase II registration clinical study for bladder cancer.

鲁维达尔TM 是一项经过同行评审的专利PDC,目前正在膀胱癌的II期注册临床研究中进行研究。

About Theralase Technologies Inc.:

关于 Theralase 科技公司:

Theralase is a clinical stage pharmaceutical company dedicated to the research and development of light activated compounds, their associated drug formulations and the light systems that activate them, with a primary objective of efficacy and a secondary objective of safety in the destruction of various cancers, bacteria and viruses.

Theralase是一家临床阶段的制药公司,致力于研究和开发光活化合物、其相关药物配方和激活它们的光系统,其主要目标是疗效,次要目标是销毁各种癌症、细菌和病毒的安全性。

Additional information is available at and

更多信息可在和

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

多伦多证券交易所风险投资交易所及其监管服务提供商(该术语在多伦多证券交易所风险交易所的政策中定义)均不对本新闻稿的充分性或准确性承担责任。

Forward Looking Statements:

前瞻性陈述:

This news release contains "forward-looking statements" within the meaning of applicable Canadian securities laws. Such statements include; but are not limited to statements regarding the Company's proposed development plans with respect to Photo Dynamic Compounds and their drug formulations. Forward looking statements may be identified by the use of the words "may, "should", "will", "anticipates", "believes", "plans", "expects", "estimate", "potential for" and similar expressions; including, statements related to the current expectations of Company's management for future research, development and commercialization of the Company's Photo Dynamic Compounds and their drug formulations, preclinical research, clinical studies and regulatory approvals.

本新闻稿包含适用的加拿大证券法所指的 “前瞻性陈述”。此类声明包括但不限于有关公司光动力化合物及其药物配方的拟议开发计划的声明。前瞻性陈述可以通过使用 “可能、“应该”、“将”、“预期”、“相信”、“计划”、“期望”、“估计”、“潜力” 等词语来识别;包括与公司管理层当前对公司光动态化合物及其药物配方、临床前研究、临床研究和监管批准的未来研究、开发和商业化预期相关的陈述。

These statements involve significant risks, uncertainties and assumptions; including, the ability of the Company to: adequately fund and secure the requisite regulatory approvals to commercially market a treatment for various cancers in a timely fashion and implement its commercialization strategy. Other risks include: the ability of the Company to successfully complete its clinical study program, access to sufficient capital to fund the Company's operations may not be available or may not be available on terms that are commercially favorable to the Company, the Company's drug formulations may not be effective against the diseases tested in its clinical studies, the Company's fails to comply with the term of license agreements with third parties and as a result loses the right to use key intellectual property in its business, the Company's ability to protect its intellectual property, the timing and success of submission, acceptance and approval of regulatory filings. Many of these factors that will determine actual results are beyond the Company's ability to control or predict.

这些陈述涉及重大风险、不确定性和假设;包括公司有能力:提供充足的资金和获得必要的监管批准,以便及时将各种癌症的治疗药物商业化销售并实施其商业化战略。其他风险包括:公司有能力成功完成其临床研究计划,可能无法获得足够的资金来资助公司的运营,或者可能无法以对公司有利的条件提供,公司的药物配方可能对临床研究中测试的疾病无效,公司未能遵守与第三方签订的许可协议条款,因此失去在其业务中使用关键知识产权的权利,公司的保护能力其知识产权、提交的时机和成功程度、监管申报的接受和批准。这些决定实际业绩的因素中有许多超出了公司的控制或预测能力。

Readers should not unduly rely on these forward-looking statements, which are not a guarantee of future performance. There can be no assurance that forward looking statements will prove to be accurate as such forward looking statements involve known and unknown risks, uncertainties and other factors which may cause actual results or future events to differ materially from the forward-looking statements.

读者不应过度依赖这些前瞻性陈述,这些陈述并不能保证未来的表现。无法保证前瞻性陈述会被证明是准确的,因为此类前瞻性陈述涉及已知和未知的风险、不确定性和其他因素,这些因素可能导致实际业绩或未来事件与前瞻性陈述存在重大差异。

Although the forward-looking statements contained in the press release are based upon what management currently believes to be reasonable assumptions, the Company cannot assure prospective investors that actual results, performance or achievements will be consistent with these forward-looking statements.

尽管新闻稿中包含的前瞻性陈述基于管理层目前认为的合理假设,但公司无法向潜在投资者保证实际业绩、业绩或成就将与这些前瞻性陈述一致。

All forward-looking statements are made as of the date hereof and are subject to change. Except as required by law, the Company assumes no obligation to update such statements.

所有前瞻性陈述均自本文发布之日起作出,可能会发生变化。除非法律要求,否则公司没有义务更新此类声明。

For More Information:

欲了解更多信息:

1.866.THE.LASE (843-5273)
416.699.LASE (5273)

1.866..LASE (843-5273)
416.699.LASE (5273)

Kristina Hachey, CPA
Chief Financial Officer
khachey@theralase.com

克里斯蒂娜·哈奇,注册会计师
首席财务官
khachey@theralase.com

SOURCE: Theralase Technologies Inc.

资料来源:Theralase Technologies


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