– A-005 was well tolerated and demonstrated ability to cross blood-brain barrier –
– Maximal TYK2 inhibition achieved with favorable pharmacokinetic profile in CNS and periphery –
– Data support advancement to Phase 2 clinical trial in multiple sclerosis, anticipated in 2H 2025 –
SOUTH SAN FRANCISCO, Calif., Dec. 19, 2024 (GLOBE NEWSWIRE) -- Alumis Inc. (NASDAQ:ALMS), a clinical stage biopharmaceutical company developing oral therapies using a precision approach to optimize clinical outcomes and significantly improve the lives of patients with immune-mediated diseases, today announced positive data from a Phase 1 clinical trial evaluating the safety, tolerability, and pharmacokinetics (PK) of single- and multiple-ascending doses of A-005, a potent, selective, central nervous system (CNS) penetrant TYK2 inhibitor, in healthy participants.
