已于10月25日向证券交易委员会申报, 2024

登记号333-

美国

证券交易委员会

华盛顿特区20549

S-8表格

根据1933年的《证券法》注册声明

$

(根据其章程规定的注册人准确名称)

Moleculin Biotech，Inc. 2024股票计划

（计划的完整名称）

Walter V. Klemp，首席执行官

Memorial Drive，Suite 950，5300

Houston，Texas 77007

（服务代理人的姓名和地址）

副本：

Cavas S.Pavri律师

ArentFox Schiff LLP

1717 K Street, NW

华盛顿，特区20006

(202) 724-6847

电话：(202)724-6847 传真：(202)778-6460 检查标记表明注册人是大型加速提交者、加速提交者、非加速提交者、小型报告公司或新兴成长公司。请参阅《证券交易法》第120亿，第2条中的“大型加速提交者”、“加速提交者”、“小型报告公司”和“新兴成长公司”的定义。(选择一个)：

用复选标记表示公司是否为大型快速审核者、加速审核者、非加速审核者、较小的报告公司或新兴成长公司。 请参阅《交易所法》第120亿.2条对“大型快速审核者”、“加速审核者”、“较小的报告公司”和“新兴成长公司”的定义：

如果是新兴成长公司，请打勾表示注册人已选择不使用延长过渡期来遵守任何新的或修订的财务会计准则，这些准则由证券法第7(a)(2)(B)条提供。 ☐

部分 I

第10(a)区间申报所需的信息

项目1。  计划信息。

注册人应向分子生物技术公司的2024年股票计划参与者提交或导致提交包含本注册声明第I部分规定信息的文件 （“2024计划”）有关的本注册声明适用的规则428(b)(1)是由证券交易委员会（“委员会”）根据1933年修订版证券法（“证券法”）发布的。注册人未向委员会提交此类文件，但这些文件（以及根据本的第II部分项目3引用并纳入本注册声明的文件），构成符合证券法第10(a)节要求的招股说明书。

事项二  注册人信息和员工计划年度信息。

根据证券法规428(b)(1)条规定，包含在根据本登记声明发送或提供给2024年计划参与者的文件中的项目2要求的书面声明。

部分 II

注册声明所需的信息

委员会允许我们“参照文档”将我们向委员会提交的某些信息纳入本注册声明中，这意味着我们正在通过指引您查阅我们向委员会提交的其他信息向您披露重要信息。我们参照文档的信息被视为本注册声明的一部分。我们明确正在参照以下向委员会提交的文件（除非根据8-K表格的一般说明而提供并未被视为“提交”的任何8-k表格的部分）：

此外，交易所法案第13(a)、13(c)、14和15(d)节要求，注册人随后根据这些规定提交的所有文件（除了根据8-k表格上的2.02或7.01项下提供的文件或其中的部分，除非在文件中另有说明，包括附带在这些项目中的任何附件），在提交表明此处提供的所有证券已经销售或撤销了所有尚未销售的证券的后生效修正案之前，将被视为通过引用并成为本注册声明的一部分，从提交这些文件的日期开始。

包含于在此处引用或被认为在此处被纳入引用的文件包含的语句，应被视为修改或取消，以便用于本次登记声明的目的，此文件中包含或后面文件的陈述中包含的声明，也被视为修改或取消了这些语句。这些修改或取消的声明，除了本次被修改或取消的声明外，不应被视为此文件的一部分。

不适用。

不适用。

Moleculin Biotech，Inc.（“MBI”）的《修正和重新制定的公司章程》和《修正和重新规定的公司章程》授权该公司对MBI的董事、高管、雇员和代理人支付其在与任何诉讼、诉讼或程序有关的实际和合理发生的费用（包括律师费）、判决、罚款和和解款项进行赔偿，前提是被赔偿方出于诚信并合理地相信自己的行为符合或不违背MBI的最佳利益，并且在任何刑事诉讼或程序方面，该方没有理由相信自己的行为是非法的。MBI的《公司章程》和《公司规定》还授权该公司对MBI的董事、高管、雇员和代理人进行赔偿，前提是该董事、高管、雇员和代理人是或曾是MBI的一方，或受到威胁成为MBI的一方，通过或以MBI请求的形式对MBI或另一实体提起、即将提起或已完成的诉讼或诉讼进行辩护或解决，并支付由其实际且合理发生的费用（包括合理的律师费），前提是他或她在诚信并并合理地相信自己的行为符合或不违背MBI的最佳利益。

MBI已与其董事和高级职员签订了赔偿协议，并可能将来与其他雇员或代理签订此类协议。 这些协议连同公司章程和注册证书可能要求MBI在其他事项中向员工或代理提供赔偿，以防特定责任发生，该责任是由于其身份或担任董事（除因故意行为导致的责任之外），提前支付发生的费用，前提是他们保证如最终由法院裁定他们无权获得赔偿，则承诺偿还预付的金额，并在合理条件下提供和保持董事和高管的保险。

MBI的公司章程规定，董事不对MBI或其股东承担个人责任，就作为一名董事而言，因侵害董事对MBI或其股东的信托责任而引起的金钱损失，除非：（i）对MBI或其股东的忠诚义务的任何违反；（ii）不诚实行为或涉及故意不端行为或明知违法行为；（iii）根据德拉华州《公司法》第174条或随时修订的任何后续条款；或（iv）董事从中获得不当个人利益的任何交易。

MBI目前拥有董事和官员责任保险。特拉华州《公司法通则》第145条以及MBI的公司章程和章程规定的对董事、董事和其他公司代表进行充分广泛的赔偿，以在特定情况下对根据《证券法》产生的责任（包括报销发生的费用）进行赔偿。

就董事、官员和控制人因有关《证券法》而产生的责任而被允许实施赔偿而言，MBI已被告知，在SEC的意见中，这种赔偿是违背公共政策的，并因此无法执行。

不适用。

以下展品作为本登记声明的一部分或被引用。

(a)        The Registrant hereby undertakes:

(1)        To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act.

(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement.

(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.

Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) herein do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are incorporated by reference in the registration statement.

(2)        That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3)        To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

(b)        The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(c)        Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Houston, Texas, on October 25, 2024.

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS that each person whose signature appears below constitutes and appoints Walter V. Klemp and Jonathan P. Foster, or any one of them, his or her true and lawful attorney-in-fact and agent, with full power of substitution, for him or her and in his or her name, place, and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same with all exhibits thereto, and other documents in connection therewith, with the Commission, granting unto such attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and ratifying and confirming all that such attorney-in-fact and agent or his or her substitute or substitutes may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed below by the following persons in the capacities and on the dates indicated: