展覽10.1

壓力位協議

這個 支持協議 （這個”協議”) 自十月起訂立並生效 [·]，2024 年，之前和之中 特拉華州的一家公司 Crescent Biopharma, Inc.（”公司”），特拉華州的一家公司 GlycoMimetics, Inc. （”父母”），以及下列簽名的股東（”股東” 以及每位股東，公司， 還有家長 a”派對” 而且，總的來說，”各方”）的公司。此處使用的大寫術語 但未另行定義應具有合併協議（定義見下文）中賦予此類術語的相應含義。

前言

鑑於，與此同時，在此文件的執行和交付之際，母公司、公司和 雙子合併子公司，一家德拉瓦州的公司，父公司的全資子公司（“第一合併公司以及 雙子合併子公司II，有限責任公司，一家特許有限責任公司（以下簡稱“第二合併子公司已進入合併及重組協議書（根據該協議條款可能不時修訂或補充，該協議稱為「合併協議」，根據此協議（i）第一個合併子公司將與公司合併，公司作為合併後的存續公司及股東全資子公司代表及（ii）公司將會與第二個合併子公司合併，第二個合併子公司將作為第二次合併的存續實體，根據合併協議中規定的條款及條件進行（統稱為「合併”).

鑒此，截至本日，股東根據《交易所法》第13d-3條的定義，擁有公司股份的股份數如下 附錄A.

鑑於， 爲了促使母公司願意訂立並進入合併協議，母公司要求股東簽訂 本協議。

現在，因此，希望得到法律約束，各方現在同意如下：

1.            某些 定義就本合併協議所指定的含義而言，在此未另行定義的大寫術語應具有合併協議中所賦予的含義。 在本協議的所有目的中，以下詞語應具有以下相應的含義：

(a)"建設性 售出”表示，就任何安防而言，對該安防進行沽空，輸入或取得關於該安防的衍生合約，在該安防上建立或取得期貨或遠期合約以交付該證券，或進行任何其他對沖或其他衍生交易，其具有直接或間接地實質改變該證券所有權的經濟利益或風險的效果。

(b)            "股份意指（i）本協議成立日股東有益擁有的所有公司資本股份，（ii）本協議簽署並交付之日起至結束日擁有並且有益擁有的所有額外公司資本股份，及（iii）本協議成立日股東無論是否目前可以轉換、行使或交換，但直接或間接持有的所有可轉換為公司資本股份的可轉換票據、本票、認股權證、期權、權利或其他證券或工具。

(c)            “轉移”或“轉讓”指任何安全性的直接或間接轉讓、出售、轉移、投標、交換、抵押、質押或留置權，或對其設立、創建或投票產生留置權、安全利益或担保，或對其作出信託的禮物、授予或設立、或通過法律控制項或其他方式對該證券的構造性出售或其他處置（包括通過遺囑或沒有遺囑的繼承、通過國內法律令或其他法院命令，或其他法律運作），或其中的任何權利、標的或利益（包括持有人可能有的任何投票權或權力，無論該權利或權力是否通過代理人或其他方式授予），或其有益所有權，以及提出進行此類出售、轉讓、構造性出售或其他處置的要約，以及為實現任何上述行為而達成的任何協議、安排或了解，無論是否以書面形式。

2.            轉讓 及投票限制。股東向母公司和公司作出以下承諾：

(a) 除外 除非另行允許 第‎2‎ (c) 節，自本協議執行和交付之日起的期限內 並在到期日（定義見下文）到期，股東不得轉讓任何股東的股份，也不得公開轉讓 宣佈打算轉讓其任何股份。

(b) 除非本協議另有規定，或者經有管轄權的法院或政府當局的訂單另有允許或要求，股東不得進行任何可能限制股東合法權力、權限和投票權，或以其他方式阻礙或使股東無法履行本協議項下義務的行為。在不限制前述一般性規定的情況下，除了本協議及本協議另行允許的情況外，股東不得與任何人或實體訂立任何有關股東持有的股份的投票協議，授予任何人或實體股份的任何代理權(可撤銷或不可撤銷)或授權書，將股份存入投票信託或以其他方式與任何人或實體訂立任何協議或安排，該協議或安排會限制或影響股東執行及交付公司股東書面同意的合法權力、權限或權利。

儘管本協議中的其他條款相反，股東可以隨時通過遺囑或其他遺囑文件或通過繼承等方式轉讓股份，直接或間接地轉讓給股東的關聯方，直接家庭成員，或者（如果股東是公司、合夥企業或其他實體）轉讓給股東持有的股份的受益所有人的直系家庭成員，轉讓給任何信託或其他實體，直接或間接地爲股東或股東的直系家庭成員或（如果股東是公司、合夥企業或其他實體）爲股東持有的股份數受益所有人的直系家庭成員提供直接或間接利益，或者出於遺產稅或遺產規劃目的，對於非自然人的股東，可以按照股東組織文件從股東向其成員、合夥人或股東進行按比例分配，從母公司根據母公司融資在收盤日期左右購買（包括母公司根據任何預資助權證轉換而發行的任何母公司股份），以及根據適用法律的要求； 在每種情況下，該B類股東和/或該B類股東的家庭成員需獨立控制在此類帳戶、計劃或信託中持有的B類普通股實時；在(i)-(v)款的情況下，轉讓的股份應繼續受本協議約束，如果未曾是該協議的一方，則這些轉讓股份的適用直接受讓人（如果有）在轉讓完成時應對母公司和公司執行並提交一份與本協議基本相同的壓力位協議。¹ 在（x）款中，這些轉讓的股份應繼續受本協議限制，在（y）款中，在轉讓完成時，這些轉讓股份的適用直接受讓人（如果有）如尚未成爲本協議的一方，則應向母公司和公司執行和提交與本協議基本相同的支持協議。

¹ 草稿注意事項PIPE股份在這些交易中通常被排除在這項義務之外，因爲在投票時PIPE股份尚未發行。至於如果適用法律要求轉讓，我們可能會試圖施加額外義務，但我們推定任何此類法律將覆蓋在此處列明的義務。

(d) 儘管本協議中有任何相反規定，但本協議中的任何內容均不會強制股東行使任何期權或其他任何權利以取得任何公司股票。

3.            同意 投票股份。股東向公司作出以下承諾：

(a) 直到 本公司任何股東大會（無論其名稱如何）以及每次休會的到期日（定義見下文）或 延期，經公司股東書面同意採取每項行動或批准後，股東應是 出示（親自或通過代理人）對股東（A）持有的所有股份進行表決，或行使同意權 贊成通過和批准合併協議，（B）贊成批准計劃中的交易，（C）反對 任何收購提案。

(b) 如果股東不是持股的記錄所有者，股東同意採取一切必要行動，以使記錄所有者和任何被提名人出席（親自或通過代理），並根據本 第3部分。

(c)            如果發生股票分割、送轉或股息分配，或由於任何分拆、股權逆市回購、資本再確定、合併、重分類、再度組織、股票交換等情況對公司資本股進行任何變更，在此類事項中，「股份」應被視爲包括這些股份以及所有這類股票送轉和分配，以及被更換或交換爲這些股份或在此類交易中收到的任何證券。

4.            行動 僅限股東身份。股東僅以股東作爲受益人的身份簽訂本協議 其股份的所有者，而不是以股東作爲公司董事或高級管理人員的身份。此處的任何內容均不限制或 影響股東擔任公司高級管理人員或董事的能力。

5.            不可更改的代理。 股東特此撤銷（或同意撤銷）其先前就其股份授予的任何代理。 如果股東未能根據本協議的規定對股份進行表決，則在有關公司股東的任何適用股東大會或根據公司股東的任何適用書面同意書之情況下，則視爲股東已不可撤銷地授予公司並委派公司及其書面指定的任何個人，以及他們中的每一個人，作爲其代理人和全權代理人（具有替代權全權），就其名義，代表其行使表決權在公司股東的任何書面同意行動中或在公司股東召集的股東大會上就協議第3部分規定的事項中的任何一項進行表決。公司同意不會行使此處授予的代理權，目的不得超出本協議描述的目的。 除本協議另有規定外（包括下一句），股東特此確認不可撤銷的代理與利益相結合，且在任何情況下均不得撤銷該不可撤銷代理且該不可撤銷代理是經過簽署並意在不可撤銷的。儘管本協議的任何其他規定，此處授予的不可撤銷代理將於到期日自動終止。 第 3 節，除非對任何股份另有明確聲明，否則股東是公司股份的受益所有者，自由清晰，不受任何留置權益的限制（除非根據本協議、股東、公司和母公司簽訂的任何限制出售協議以及適用證券或其他社區財產法律下產生的留置權益的影響）；而且 (ii) 股東除公司股本和購買公司股本的權利之外，不擁有公司的任何證券。在公司股東的任何適用股東大會或根據公司股東的任何適用書面同意書之情況下 第 3 節，除非對任何股份另有明確聲明，否則股東是公司股份的受益所有者，自由清晰，不受任何留置權益的限制（除非根據本協議、股東、公司和母公司簽訂的任何限制出售協議以及適用證券或其他社區財產法律下產生的留置權益的影響）；而且 (ii) 股東除公司股本和購買公司股本的權利之外，不擁有公司的任何證券。本協議第3部分規定的事項，且按照和一致於

6.            不 接受招攬股東同意不會直接或間接地，包括通過其任何高管、董事或代理人，採取任何公司依據併購協議第5.4節和併購協議第5.4節禁止採取的行動，特此參照併入。 必要時修改.

7.            文檔和信息股東應允許，並特此授權母公司和公司在與併購及相關交易有關的所有提交給美國證券交易委員會的文件和日程安排，以及母公司或公司合理確定爲必要的任何新聞發佈或其他披露文件中，披露本協議的副本，股東的身份和股份所有權以及股東在本協議項下的承諾和義務性質；但母公司和公司應提前向股東提供此類文件、日程、新聞發佈或其他披露文件供其審查和意見。母公司和公司均是本協議的受益方之一 第 7 條.

8.            不 行使評估權利；放棄權利。股東在此不可撤銷地、無條件地(a)放棄，並同意導致或阻止行使任何評估權利、任何持異議者權利和任何類似權利（包括與此相關的任何通知要求），關於股東可能因持有股份而擁有的、或關於合併的與之相關的任何股份（包括所有根據DGCL第262條的權利）；以及(b)同意股東不會提出、發起、成立、維持、提起或自願援助或參與任何訴訟、索賠、訴訟或法律或公正地在任何法院或在任何政府部門之前參與的行動，其中(i)挑戰本協議的任何條款的有效性或試圖禁止該協議的執行，或(ii)聲稱股東簽署和交付本協議違反了股東對本公司或其他公司股東可能擁有的（或可能被指控擁有）的任何義務； 在每種情況下，該B類股東和/或該B類股東的家庭成員需獨立控制在此類帳戶、計劃或信託中持有的B類普通股實時；，（x）股東可以爲協議以獨立身份作爲公司董事、高管或持股人在股東自身之權利下，爲所提出的針對股東的任何此類訴訟、索賠、訴訟或原本訴訟進行辯護、爭議或和解，（y）前述不限制或限制股東以任何方式執法本協議及股東與本協議相關的其他協議，或以其他方式與合併有關的任何協議，包括根據合併協議條款收到合併對價的股東權利。

9.            股東的陳述與擔保股東特此向母公司和公司作出以下聲明和保證：

(a)            (i) 股東是公司股本中所示股份的受益所有人，所有這些股份均是股東自由清晰的，除了根據本協議可加以施加的任何留置權利，由股東、公司和母公司簽訂的任何限制出售協議，以及根據適用證券或其他社區財產法律產生的任何留置權利；和 (ii) 股東除了公司股本和購買公司股本的權利所示，不另外擁有公司的任何證券。 附錄A （每一份均被視爲股東持有，目的是（無論是否明確說明，均與任何股份有關)自由清晰，除了可能根據本協議施加的任何留置權利，由股東、公司和母公司簽訂的任何限制出售協議以及適用證券或其他社區財產法律下產生的任何留置權利；(ii) 股東除了公司股本和購買公司股本的權利所示，不另外擁有公司的任何證券。 第 3 節，除非對任何股份另有明確聲明，否則股東是公司股份的受益所有者，自由清晰，不受任何留置權益的限制（除非根據本協議、股東、公司和母公司簽訂的任何限制出售協議以及適用證券或其他社區財產法律下產生的留置權益的影響）；而且 (ii) 股東除公司股本和購買公司股本的權利之外，不擁有公司的任何證券。 ），自由清晰，不受任何留置權益的限制，（除了根據本協議、股東、公司和母公司簽訂的任何限制出售協議的約束以及適用證券或其他社區財產法律下產生的留置權益）；而且 (ii) 股東除公司股本和購買公司股本的權利之外，不擁有公司的任何證券。 附錄A），自由清晰，不受任何留置權益的限制，（除了根據本協議、股東、公司和母公司簽訂的任何限制出售協議的約束以及適用證券或其他社區財產法律下產生的留置權益）；而且 (ii) 股東除公司股本和購買公司股本的權利之外，不擁有公司的任何證券。 附錄A.

(b) 除非本協議另有規定，股東有充分的權力和授權：(i)簽訂並執行本協議的條款，(ii)根據本協議中規定的方式投票支持其所持有的所有股份，無需得到其他任何個人或實體（包括任何政府機構）的同意或批准，或採取任何其他行動。在不限制前述一般性規定的前提下，股東未與任何人簽訂與其所持股票有關的任何投票協議（除本協議外），未向任何人提供有關其所持股份的任何（可撤銷或不可撤銷的）授權委託書或代理權，未將其所持股份存入投票信託或與他人簽訂任何限制或影響其合法投票權利的安排或協議。

本協議已由股東合法有效地簽署並交付，並（假定其他各方已經獲得授權、簽署和交付）構成股東可依照協議條款執行的有效且具約束力的協議，但受強制執行例外的限制。股東簽署並交付本協議，以及根據本協議在此做出的協議和義務的履行，不會導致任何合同條款的違反或違背或與之相沖突或構成違約，不會違反股東作爲一方或受約束方參與的任何合同或（如適用）其組織文件（包括註冊證書）的條款，也不會違反股東（或其任何資產）受約束或受制於的任何適用法律的規定，除非任何此類違反、違例、衝突或違約在單獨或累積的情況下均不會合理地預期對股東履行本協議項下義務造成實質性損害或不利影響。

(d)            本協議由股東執行、交付和履行，不需要任何政府機構的同意、批准、授權或許可，除非沒有作出或獲得此類同意、批准、授權、許可、行動、申報或通知將不能或無法單獨或總體上重大影響股東履行本協議項下的義務。

(e)            The Stockholder has had the opportunity to review the Merger Agreement and this Agreement with counsel of the Stockholder’s own choosing. The Stockholder has had an opportunity to review with its own tax advisors the tax consequences of the Merger and the Contemplated Transactions. The Stockholder understands that it must rely solely on its advisors and not on any statements or representations made by Parent, the Company or any of their respective agents or representatives with respect to the tax consequences of the Merger and the Contemplated Transactions. The Stockholder understands that such Stockholder (and not Parent, the Company or the Surviving Entity) shall be responsible for such Stockholder’s tax liability that may arise as a result of the Merger or the Contemplated Transactions. The Stockholder understands and acknowledges that the Company, Parent and Merger Sub are entering into the Merger Agreement in reliance upon the Stockholder’s execution, delivery and performance of this Agreement.

(f)            With respect to the Stockholder, as of the date hereof, there is no action, suit, investigation or proceeding pending against, or, to the knowledge of the Stockholder, threatened against, the Stockholder or any of the Stockholder’s properties or assets (including the Shares) that would reasonably be expected to prevent or materially delay or impair the ability of the Stockholder to perform its obligations hereunder or to consummate the transactions contemplated hereby.

10.            Certain Agreements. Each Stockholder, by this Agreement, and with respect to such Stockholder’s Shares, severally and not jointly, hereby agrees to terminate, subject to the occurrence of, and effective immediately prior to, the First Effective Time any rights under any letter agreement providing for redemption rights, put rights, purchase rights, information rights, rights to consult with and advise management, inspection rights, preemptive rights, board of directors observer rights or rights to receive information delivered to the board of directors or other similar rights not generally available to stockholders of the Company between the Stockholder and the Company, but excluding, for the avoidance of doubt, any rights the Stockholder may have that relate to any indemnification, commercial, development or employment agreements or arrangements between such Stockholder and the Company or any subsidiary of the Company, which shall survive in accordance with their terms. Each Stockholder hereby terminates and waives all rights of first refusal, redemption rights and rights of notice of the Merger and the other transactions contemplated by the Merger Agreement, effective as of immediately prior to, and contingent upon, the First Effective Time.

11.            Termination. This Agreement shall terminate and shall cease to be of any further force or effect as of the earliest of (a) such date and time as the Merger Agreement shall have been terminated pursuant to the terms thereof as in effect on the date of this Agreement (and without giving effect to any amendments thereto unless consented to by the Stockholder), (b) the First Effective Time and (c) the time this Agreement is terminated upon the written agreement of the Stockholder, the Company and Parent (the “Expiration Date”); provided, however, that (i) Section ‎12 shall survive the termination of this Agreement and (ii) the termination of this Agreement shall not relieve any Party from any liability for any material and willful breach of this Agreement prior to the First Effective Time.

12.            Miscellaneous Provisions.

(a)            Amendments. No amendment of this Agreement shall be effective against any Party unless it shall be in writing and signed by each of the Parties.

(b)            Entire Agreement; Counterparts; Exchanges by Electronic Transmission or Facsimile. This Agreement constitutes the entire agreement between the Parties and supersedes all other prior agreements, arrangements and understandings, both written and oral, among the Parties with respect to the subject matter hereof. This Agreement may be executed in several counterparts, each of which shall be deemed an original and all of which shall constitute one and the same instrument. The exchange of a fully executed Agreement (in counterparts or otherwise) by all Parties by facsimile or electronic transmission in PDF format shall be sufficient to bind the Parties to the terms and conditions of this Agreement.

(c)            Applicable Law; Jurisdiction. This Agreement shall be governed by, and construed in accordance with, the laws of the State of Delaware, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws. In any action or proceeding between any of the Parties arising out of or relating to this Agreement, each of the Parties: (i) irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Court of Chancery of the State of Delaware or, to the extent such court does not have subject matter jurisdiction, the Superior Court of the State of Delaware or the United States District Court for the District of Delaware, (ii) agrees that all claims in respect of such action or proceeding shall be heard and determined exclusively in accordance with clause (i) of this Section ‎12‎‎(c), (iii) waives any objection to laying venue in any such action or proceeding in such courts, (iv) waives any objection that such courts are an inconvenient forum or do not have jurisdiction over any Party, (v) agrees that service of process upon such Party in any such action or proceeding shall be effective if notice is given in accordance with Section ‎12‎(h) of this Agreement and (vi) irrevocably and unconditionally waives the right to trial by jury.

(d)            Assignment. This Agreement shall be binding upon, and shall be enforceable by and inure solely to the benefit of, the Parties and their respective successors and permitted assigns; provided, however, that neither this Agreement nor any of a Party’s rights or obligations hereunder may be assigned or delegated (except pursuant to the Merger) by such Party without the prior written consent of the other Parties, and any attempted assignment or delegation of this Agreement or any of such rights or obligations by such Party without the other Parties’ prior written consent shall be void and of no effect.

(e)            No Third-Party Rights. Nothing in this Agreement, express or implied, is intended to or shall confer upon any Person any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement.

(f)             Severability. Any term or provision of this Agreement that is invalid or unenforceable in any situation in any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this Agreement or the validity or enforceability of the offending term or provision in any other situation or in any other jurisdiction. If a final judgment of a court of competent jurisdiction declares that any term or provision of this Agreement is invalid or unenforceable, the Parties agree that the court making such determination shall have the power to limit such term or provision, to delete specific words or phrases or to replace such term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable term or provision, and this Agreement shall be valid and enforceable as so modified. In the event such court does not exercise the power granted to it in the prior sentence, the Parties agree to replace such invalid or unenforceable term or provision with a valid and enforceable term or provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term or provision.

(g)            Specific Performance. Except as otherwise provided herein, any and all remedies herein expressly conferred upon a Party will be deemed cumulative with and not exclusive of any other remedy conferred hereby, or by law or equity upon such Party, and the exercise by a Party of any one remedy will not preclude the exercise of any other remedy. The Parties agree that irreparable damage for which monetary damages, even if available, would not be an adequate remedy, would occur in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms (including failing to take such actions as are required of it hereunder to consummate this Agreement) or were otherwise breached. It is accordingly agreed that the Parties shall be entitled to an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions hereof the Court of Chancery of the State of Delaware or, to the extent such court does not have subject matter jurisdiction, the Superior Court of the State of Delaware or the United States District Court for the District of Delaware, this being in addition to any other remedy to which they are entitled at law or in equity, and each of the Parties waives any bond, surety or other security that might be required of any other Party with respect thereto. Each of the Parties further agrees that it will not oppose the granting of an injunction, specific performance or other equitable relief on the basis that any other Party has an adequate remedy at law or that any award of specific performance is not an appropriate remedy for any reason at law or in equity.

(h)            Notices. All notices and other communications hereunder shall be in writing and shall be deemed duly delivered (i) one (1) Business Day after being sent for next Business Day delivery, fees prepaid, via a reputable international overnight courier service, (ii) upon delivery in the case of delivery by hand or (iii) on the date delivered in the place of delivery if sent by email or facsimile (with a written or electronic confirmation of delivery) prior to 6:00 p.m. (New York City time), otherwise on the next succeeding Business Day, (A) if to the Company or Parent, to the address, electronic mail address or facsimile provided in Section 11.7 of the Merger Agreement, including to the persons designated therein to receive copies; and/or (B) if to the Stockholder, to the Stockholder’s address, electronic mail address or facsimile shown below Stockholder’s signature to this Agreement.

(i)             Confidentiality. Except to the extent required by applicable Law or regulation, the Stockholder shall hold any non-public information regarding the Company, this Agreement, the Merger Agreement and the Merger in strict confidence and shall not divulge any such information to any third person until the Company and Parent have publicly disclosed their entry into the Merger Agreement and this Agreement; provided, however, that the Stockholder may disclose such information to its Affiliates, attorneys, accountants, consultants, and other advisors (provided that such Persons are subject to confidentiality obligations at least as restrictive as those contained herein). Neither the Stockholder nor any of its Affiliates (other than the Company, whose actions shall be governed by the Merger Agreement), shall issue or cause the publication of any press release or other public announcement with respect to the Company, this Agreement, the Merger, the Merger Agreement or the other transactions contemplated hereby or thereby without the prior written consent of the Company and Parent, except as may be required by applicable Law in which circumstance such announcing Party shall make reasonable efforts to consult with the Company and Parent to the extent practicable.

(j)             Interpretation. The words “hereof,” “herein” and “hereunder” and words of like import used in this Agreement shall refer to this Agreement as a whole and not to any particular provision of this Agreement. The captions herein are included for convenience of reference only and shall be ignored in the construction or interpretation hereof. References to Sections and Appendixes are to Sections and Appendixes of this Agreement unless otherwise specified. Any capitalized terms used in any Appendix but not otherwise defined therein shall have the meaning as defined in this Agreement. Any singular term in this Agreement shall be deemed to include the plural, and any plural term the singular, the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include masculine and feminine gender. Whenever the words “include,” “includes” or “including” are used in this Agreement, they shall be deemed to be followed by the words “without limitation,” whether or not they are in fact followed by those words or words of like import. The word “or” is not exclusive. “Writing,” “written” and comparable terms refer to printing, typing and other means of reproducing words (including electronic media) in a visible form. References to any agreement or Contract are to that agreement or Contract as amended, modified or supplemented from time to time in accordance with the terms hereof and thereof. References to any Person include the successors and permitted assigns of that Person. References to any statute are to that statute and to the rules and regulations promulgated thereunder, in each case as amended, modified, re-enacted thereof, substituted, from time to time. References to “$” and “dollars” are to the currency of the United States. All accounting terms used herein will be interpreted, and all accounting determinations hereunder will be made, in accordance with GAAP unless otherwise expressly specified. References from or through any date shall mean, unless otherwise specified, from and including or through and including, respectively. All references to “days” shall be to calendar days unless otherwise indicated as a “Business Day.” Except as otherwise specifically indicated, for purposes of measuring the beginning and ending of time periods in this Agreement (including for purposes of “Business Day” and for hours in a day or Business Day), the time at which a thing, occurrence or event shall begin or end shall be deemed to occur in the Eastern time zone of the United States. The Parties agree that any rule of construction to the effect that ambiguities are to be resolved against the drafting Party shall not be applied in the construction or interpretation of this Agreement.

[Remainder of Page Left Intentionally Blank]

IN WITNESS WHEREOF, the undersigned have caused this Agreement to be duly executed as of the date first above written.

COMPANY:

Crescent Biopharma, Inc.

[Signature Page to Company Stockholder Support Agreement]

Parent:

GlycoMimetics, Inc.,

[Signature Page to Company Stockholder Support Agreement]

[STOCKHOLDER],

in his/her capacity as the Stockholder:

[Signature Page to Company Stockholder Support Agreement]

Appendix A