证券交易委员会
华盛顿特区20549
13G表格
（13d-102规定）
根据13d-1 (b), (c)和(d)规定，应包含在提交的报表中的信息
及根据13d-2(b)所递交的修正案
(修正案编号___________)*
莱尔免疫制药公司。
（发行人名称）
普通股，面值$0.0001
（证券种类的标题）
55083R104
（CUSIP编号）
2024年10月25日
（需要提交此声明的事件的日期）
请勾选适用于此附表的规则：
¨规则13d-1(b)
x规则13d-1(c)
¨规则13d-1(d)
*此封面页面的其余部分应由提交人填写 关于主体证券类别的此表格的初始申报，以及包含任何会改变先前封面页面提供的披露的信息的任何后续修订。
在本封面上所需的其他信息不应视为根据1934年证券交易法（“法案”）第18条的规定而进行“备案”，也不应视为受该法案该部分的任何责任，但应受该法案的所有其他规定的约束（但请参阅注释）。
(续下页)
第1页，共10页
第9页的展示指数
| CUSIP编号55083R104 | 第2页，共16页 |
| 1 | 报告人名称 | Foresite Capital IV基金（“FCF IV”） |
| 2 | 如果是一组的成员，请检查适当的框（见说明书） | |
| (a) ¨ (b) x | ||
| 3 | 仅供SEC使用 | |
| 4 | 公民身份或组织地点 特拉华 | |
| 持有
股份的数量 股份 受益人 报告人拥有的股票。 个人 未知 |
5 | 唯一拥有投票权的股份数量 8,325,000股，除非Foresite Capital Management IV，LLC（“FCm IV”），FCF IV的普通合伙人可以被视为拥有投票这些股票的唯一权力，以及FCm IV的董事总经理詹姆斯·塔南鲍姆（“Tananbaum”）可被视为拥有投票这些股票的唯一权力。 |
| 6 | 具有共同投票权 请参见第5行的响应。 | |
| 7 |
具有唯一处理权 8,325,000股，除非FCm IV的普通合伙人FCF IV可能被视为拥有独立处置这些股份的权力，以及FCm IV的管理成员Tananbaum可能被视为拥有独立处置这些股份的权力。 | |
| 8 | 具有共同处理权 请参见第7行的响应。 |
| 9 | 每位报告人受益拥有的合计数量 | 8,325,000 |
| 10 | 如果第9行的总额不包括某些股份，请勾选复选框 | ¨ |
| 11 | 占第9行金额的类别的百分比 | 3.2%1 |
| 12 | 报告人类型 | PN |
1该百分比是根据以下计算的 256,593,235 作为2024年10月23日起草的联合免疫药物有限公司普通股，详见2024年10月24日提交给证券交易委员会的8-k表2.1附表。
| CUSIP编号55083R104 | 第16页的第3页 |
| 1 | 报告人名称 | Foresite Capital Management IV, LLC（“FCm IV”） |
| 2 | 如果是一组的成员，请检查适当的框（见说明书） | |
| (a) ¨ (b) x | ||
| 3 | 仅供SEC使用 | |
| 4 | 公民身份或组织地点 特拉华 | |
| 持有
股份的数量 股份 受益人 报告人拥有的股票。 个人 未知 |
5 | 唯一拥有投票权的股份数量 8,325,000股，所有板块均由FCF IV直接持有。 FCF IV的普通合伙人FCm IV可能被视为拥有这些股份的唯一表决权，而FCm IV的管理成员Tananbaum可能被视为拥有这些股份的唯一表决权。 |
| 6 | 具有共同投票权 请参见第5行的响应。 | |
| 7 | 具有唯一处理权 832.5万股，所有板块直接由FCF IV所有。FCm IV，FCF IV的普通合伙人，可能被视为拥有处置这些股份的唯一权力，而FCm IV的管理成员Tananbaum可能被视为拥有处置这些股份的唯一权力。 | |
| 8 | 具有共同处理权 请参见第7行的响应。 |
| 9 | 每位报告人受益拥有的合计数量 | 8,325,000 |
| 10 | 如果第9行的合计金额不包括某些股票，请勾选复选框 | ¨ |
| 11 | 第9行的金额所代表的股份比例 | 3.2%2 |
| 12 | 报告人类型 | OO |
2 此百分比是基于Issuer于2024年10月23日的流通普通股计算的，如Issuer提交给证券交易委员会的8-k表格附件2.1所示。 256,593,235 作为于2024年10月24日提交给证券交易委员会的8-k表格附件2.1中规定的Issuer流通普通股的基准。
| CUSIP编号55083R104 | 第16页中的第4页 |
| 1 | 报告人名称 | Foresite Capital基金V，有限合伙（“FCF V”） |
| 2 | 如果是一组的成员，请检查适当的框（见说明书） | |
| (a) ¨ (b) x | ||
| 3 | 仅供SEC使用 | |
| 4 | 公民身份或组织地点 特拉华 | |
| 持有
股份的数量 股份 受益人 报告人拥有的股票。 个人 未知 |
5 | 唯一拥有投票权的股份数量 3,907,500股，但Foresite Capital Management V, LLC（“FCm V”），FCF V的普通合伙人，可能被视为拥有这些股票的唯一表决权，而FCm V的董事总经理Tananbaum可能被视为拥有这些股票的唯一表决权。 |
| 6 | 具有共同投票权 请参见第5行的响应。 | |
| 7 |
具有唯一处理权 3,907,500股，除FCm V的普通合伙人FCF V可能被认定为有单独处置这些股份的唯一权力外，FCm V的管理成员Tananbaum可能被认定为有单独处置这些股份的唯一权力。 | |
| 8 | 具有共同处理权 请参见第7行的响应。 |
| 9 | 每位报告人受益拥有的合计数量 | 3,907,500 |
| 10 | 如果第9行的合计金额不包括某些股票，请勾选复选框 | ¨ |
| 11 | 行9金额所代表的类别占比 | 1.5%3 |
| 12 | 报告人类型 | PN |
3该百分比是根据以下计算的 256,593,235 2024年10月23日，根据交易所提交给证券交易委员会的8-k表格附件2.1，发行人未流通普通股数量。
| CUSIP编号55083R104 | 第5页，共16页 |
| 1 | 报告人名称 | Foresite Capital Management V, LLC（"FCm V"） |
| 2 | 如果是一组的成员，请检查适当的框（见说明书） | |
| (a) ¨ (b) x | ||
| 3 | 仅供SEC使用 | |
| 4 | 公民身份或组织地点 特拉华 | |
| 持有
股份的数量 股份 受益人 报告人拥有的股票。 个人 未知 |
5 | 唯一拥有投票权的股份数量 3,907,500股，所有板块直接由FCF V拥有。 FCF V的普通合伙者FCm V可能被视为拥有这些股份的唯一表决权，FCm V的管理成员Tananbaum可能被视为拥有这些股份的唯一表决权。 |
| 6 | 具有共同投票权 请参见第5行的响应。 | |
| 7 | 具有唯一处理权 3,907,500股，不过，FCm V的普通合伙人FCF V可能被认定为拥有单独处置这些股份的唯一权力，而FCm V的管理成员Tananbaum可能被认为拥有单独处置这些股份的唯一权力。 | |
| 8 | 具有共同处理权 请参见第7行的响应。 |
| 9 | 每位报告人受益拥有的合计数量 | 3,907,500 |
| 10 | 如果第9行的合计金额不包括某些股票，请勾选复选框 | ¨ |
| 11 | 第9行的金额所代表的股份比例 | 1.5%4 |
| 12 | 报告人类型 | OO |
4 此百分比是基于Issuer于2024年10月23日的流通普通股计算的，如Issuer提交给证券交易委员会的8-k表格附件2.1所示。 256,593,235 2024年10月23日，根据交易所提交给证券交易委员会的8-k表格附件2.1，发行人未流通普通股数量。
| CUSIP编号55083R104 | 第6页，共16页 |
| 1 | 报告人名称 | Foresite Capital Opportunity Fund V, L.P.（FCF Opp V） |
| 2 | 如果是一组的成员，请检查适当的框（见说明书） | |
| (a) ¨ (b) x | ||
| 3 | 仅供SEC使用 | |
| 4 | 公民身份或组织地点 特拉华 | |
| 持有
股份的数量 股份 受益人 报告人拥有的股票。 个人 未知 |
5 | 唯一拥有投票权的股份数量 1,451,358股，除非Foresite Capital Opportunity Management V, LLC（“FCm Opp V”），FCF Opp V的普通合伙人，可以被视为拥有这些股份的唯一表决权，并且FCm Opp V的管理成员Tananbaum可以被视为拥有这些股份的唯一表决权。 |
| 6 | 具有共同投票权 请参见第5行的响应。 | |
| 7 |
具有唯一处理权 1,451,358股，除FCm Opp V的普通合伙人FCF Opp V的General Partner之外，可能被视为拥有这些股份的独立处置权，而FCm Opp V的管理成员Tananbaum可能被视为拥有这些股份的独立处置权。 | |
| 8 | 具有共同处理权 请参见第7行的响应。 |
| 9 | 每位报告人受益拥有的合计数量 | 1,451,358 |
| 10 | 如果第9行的合计金额不包括某些股票，请勾选复选框 | ¨ |
| 11 | 第9行的金额所代表的股份比例 | 0.6%5 |
| 12 | 报告人类型 | PN |
5 此百分比是基于Issuer于2024年10月23日的流通普通股计算的，如Issuer提交给证券交易委员会的8-k表格附件2.1所示。 256,593,235 2024年10月23日，根据交易所提交给证券交易委员会的8-k表格附件2.1，发行人未流通普通股数量。
| CUSIP编号55083R104 | 第16页的第7页 |
| 1 | 报告人名称 | Foresite Capital 机会管理 V, LLC（“FCM Opp V”） |
| 2 | 如果是一组的成员，请检查适当的框（见说明书） | |
| (a) ¨ (b) x | ||
| 3 | 仅供SEC使用 | |
| 4 | 公民身份或组织地点 特拉华 | |
| 持有
股份的数量 股份 受益人 报告人拥有的股票。 个人 未知 |
5 | 唯一拥有投票权的股份数量 1,451,358股，所有板块直接由FCF Opp V所有。 FCF Opp V的普通合伙人FCm Opp V可能被视为拥有这些股份的唯一表决权，而FCm Opp V的管理成员Tananbaum可能被视为拥有这些股份的唯一表决权。 |
| 6 | 具有共同投票权 请参见第5行的响应。 | |
| 7 | 具有唯一处理权 1,451,358股全部直接属于FCF Opp V持有。FCm Opp V的普通合伙人可能被视为拥有处置这些股份的唯一权力，而FCm Opp V的管理成员Tananbaum可能被视为拥有处置这些股份的唯一权力。 | |
| 8 | 具有共同处理权 请参见第7行的响应。 |
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 1,451,358 |
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES | ¨ |
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 0.6%6 |
| 12 | TYPE OF REPORTING PERSON | OO |
6 This percentage is calculated based upon 256,593,235 Common Stock outstanding of the Issuer as of October 23, 2024, as set forth in Exhibit 2.1 to the Issuer’s Form 8-K filed with the Securities and Exchange Commission on October 24, 2024.
| CUSIP # 55083R104 | Page 8 of 16 |
| 1 | NAME OF REPORTING PERSONS | James Tananbaum (“Tananbaum”) |
| 2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | |
| (a) ¨ (b) x | ||
| 3 | SEC USE ONLY | |
| 4 | CITIZENSHIP OR PLACE OF ORGANIZATION United States | |
| NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
5 | SOLE VOTING POWER 13,683,858 shares, all of which 8,325,000 shares are directly owned by FCF IV, 3,907,500 shares are directly owned by FCF V and 1,451,358 shares are directly owned by FCF Opp V. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V and FCM Opp V, which is the general partner of FCF Opp V. Tananbaum may be deemed to have sole power to vote these shares. |
| 6 | SHARED VOTING POWER See response to row 5. | |
| 7 | SOLE DISPOSITIVE POWER 13,683,858 shares, all of which 8,325,000 shares are directly owned by FCF IV, 3,907,500 shares are directly owned by FCF V and 1,451,358 shares are directly owned by FCF Opp V. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V and FCM Opp V, which is the general partner of FCF Opp V. Tananbaum may be deemed to have sole power to dispose of these shares. | |
| 8 | SHARED DISPOSITIVE POWER See response to row 7. |
| 9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | 13,683,858 |
| 10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES | ¨ |
| 11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | 5.3%7 |
| 12 | TYPE OF REPORTING PERSON | IN |
7 This percentage is calculated based upon 256,593,235 Common Stock outstanding of the Issuer as of October 23, 2024, as set forth in Exhibit 2.1 to the Issuer’s Form 8-K filed with the Securities and Exchange Commission on October 24, 2024.
| CUSIP # 55083R104 | Page 9 of 16 |
| ITEM 1(A). | NAME OF ISSUER |
Lyell Immunopharma, Inc. (the “Issuer”)
| ITEM 1(B). | ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICES |
201 Haskins Way
South San Francisco, California 94080
| ITEM 2(A). | NAME OF PERSONS FILING |
This Schedule is filed by Foresite Capital Fund IV, L.P., a Delaware limited partnership (“FCF IV”), Foresite Capital Management IV, LLC, a Delaware limited liability company (“FCM IV”), Foresite Capital Fund V, L.P., a Delaware limited partnership (“FCF V”), Foresite Capital Management V, LLC, a Delaware limited liability company (“FCM V”), Foresite Capital Opportunity Fund V, L.P., a Delaware limited partnership (“FCF Opp V”), Foresite Capital Opportunity Management V, LLC, a Delaware limited liability company (“FCM Opp V”) and James Tananbaum. The foregoing entities and individuals are collectively referred to as the “Reporting Persons.”
| ITEM 2(B). | ADDRESS OF PRINCIPAL OFFICE |
The address for each of the Reporting Persons is:
c/o Foresite Capital Management
900 Larkspur Landing Circle, Suite 150
Larkspur, CA 94939
| ITEM 2(C). | CITIZENSHIP |
See Row 4 of cover page for each Reporting Person.
| ITEM 2(D). | TITLE OF CLASS OF SECURITIES |
Common Stock, par value $0.0001
| ITEM 2(E) | CUSIP NUMBER |
55083R104
| ITEM 3. | If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: |
Not applicable.
| ITEM 4. | OWNERSHIP |
The following information with respect to the ownership of the Common Stock of the Issuer by the persons filing this Statement is provided as of October 25, 2024:
| CUSIP # 55083R104 | Page 10 of 16 |
| (a) | Amount beneficially owned: |
See Row 9 of cover page for each Reporting Person.
| (b) | Percent of Class: |
See Row 11 of cover page for each Reporting Person.
| (c) | Number of shares as to which such person has: |
| (i) | Sole power to vote or to direct the vote: |
See Row 5 of cover page for each Reporting Person.
| (ii) | Shared power to vote or to direct the vote: |
See Row 6 of cover page for each Reporting Person.
| (iii) | Sole power to dispose or to direct the disposition of: |
See Row 7 of cover page for each Reporting Person.
| (iv) | Shared power to dispose or to direct the disposition of: |
See Row 8 of cover page for each Reporting Person.
| ITEM 5. | OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS |
Not applicable.
| ITEM 6. | OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON. |
Under certain circumstances set forth in the limited partnership agreements of FCF IV, FCF V and FCF Opp V and the limited liability company agreements of FCM IV, FCM V and FCM Opp V, the partners or members, as the case may be, of each of such entities may be deemed to have the right to receive dividends from, or the proceeds from the sale of, shares of the Issuer directly or indirectly owned by each such entity of which they are a partner or member.
| ITEM 7. | IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY |
Not applicable.
| ITEM 8. | IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP. |
Not applicable
| ITEM 9. | NOTICE OF DISSOLUTION OF GROUP. |
Not applicable
| CUSIP # 55083R104 | Page 11 of 16 |
| ITEM 10. | CERTIFICATION. |
By signing below, I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
| CUSIP # 55083R104 | Page 12 of 16 |
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: October 31, 2024
| FORESITE CAPITAL FUND IV, L.P. | |||
| By: | FORESITE CAPITAL MANAGEMENT IV, LLC | ||
| Its: | General Partner | ||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL MANAGEMENT IV, LLC | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL FUND V, L.P. | |||
| By: | FORESITE CAPITAL MANAGEMENT V, LLC | ||
| Its: | General Partner | ||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL MANAGEMENT V, LLC | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL OPPORTUNITY FUND V, L.P. | |||
| By: | FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC | ||
| Its: | General Partner | ||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| CUSIP # 55083R104 | Page 13 of 16 |
| FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| JAMES TANANBAUM | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| CUSIP # 55083R104 | Page 14 of 16 |
EXHIBIT INDEX
| Found on Sequentially | ||
| Exhibit | Numbered Page | |
| Exhibit A: Agreement of Joint Filing | 10 |
| CUSIP # 55083R104 | Page 15 of 16 |
exhibit A
Agreement of Joint Filing
The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the Common Stock of the Issuer shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13G.
Date: October 31, 2024
| FORESITE CAPITAL FUND IV, L.P. | |||
| By: | FORESITE CAPITAL MANAGEMENT IV, LLC | ||
| Its: | General Partner | ||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL MANAGEMENT IV, LLC | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL FUND V, L.P. | |||
| By: | FORESITE CAPITAL MANAGEMENT V, LLC | ||
| Its: | General Partner | ||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL MANAGEMENT V, LLC | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| FORESITE CAPITAL OPPORTUNITY FUND V, L.P. | |||
| By: | FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC | ||
| Its: | General Partner | ||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| CUSIP # 55083R104 | Page 16 of 16 |
| FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||
| Title: | Managing Member | ||
| JAMES TANANBAUM | |||
| By: | /s/ James Tananbaum | ||
| Name: | James Tananbaum | ||