Bradykinin Symposium 2024、HAEi全球血管性水肿论坛以及美国变态反应、哮喘和免疫学学会（ACAAI）年会上的演示重点放在了针对deucrictibant预防性和按需治疗的积极长期延期数据。 Extension data confirm the observed safety and tolerability profile from Phase 2 randomized studies and further support the potential for deucrictibant to become a preferred therapy for the management of HAE. Long-term prophylaxis extension data of deucrictibant (CHAPTER-1 OLE) show attack reduction is maintained for over one year with open-label extension participants experienced a 93% reduction in attacks compared to baseline. Long-term on-demand extension data of deucrictibant immediate-release capsule (RAPIDe-2 OLE) show median onset of symptom relief in ~1.1 hours, with 85.8% of attacks resolving
completely within 24 hours. The full posters and presentation slides are available on the Investors section of the Pharvaris website at https://ir.pharvaris.com/news-events/publications.
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Announced plans to expand clinical development of deucrictibant into acquired angioedema due to C1-INH deficiency (AAE-C1INH) following publication of compelling data from an investigator-initiated trial. Data in the July 2024 publication of the Journal of Allergy and Clinical Immunology explored the potential for deucrictibant to address the unmet medical need for effective and well-tolerated therapies for the prophylactic and on-demand treatment of AAE-C1INH. Currently, there are no approved therapies to address AAE-C1INH. A randomized, double-blind, placebo-controlled study was conducted by Investigators at the Amsterdam University Medical Center (Amsterdam UMC). Three persons living with AAE-C1INH were enrolled; the individual mean monthly attack rates were 2.0, 0.6, and 1.0 during the placebo period and 0.0 across all participants during treatment with deucrictibant. There were no severe adverse events and one self-limiting treatment-emergent adverse event (abdominal pain).
