0.30Open0.46Pre Close14 Volume8.98K Open Interest15.00Strike Price418.00Turnover621.56%IV171.28%PremiumDec 20, 2024Expiry Date0.00Intrinsic Value100Multiplier6DDays to Expiry0.30Extrinsic Value100Contract SizeAmericanOptions Type0.1969Delta0.0626Gamma16.11Leverage Ratio-0.1031Theta0.0001Rho3.17Eff Leverage0.0020Vega
Trytosaveabit OP : Preliminary data supports BMF-500's potential as a transformative therapy for patients with FLT3 mutated relapsed or refractory (R/R) acute leukemia
BMF-500 showed a favorable safety and tolerability profile, with no dose-limiting toxicities observed across all dose levels
Pharmacokinetic and pharmacodynamic data confirmed on-target FMS-like tyrosine kinase 3 (FLT3) inhibition, demonstrating dose-proportional activity and good compartmental penetration
Preliminary Phase I data for BMF-500 in R/R acute leukemia patients with FLT3 gene mutations having failed gilteritinib indicated clinical activity with evidence of responses, including a first complete response with incomplete hematologic recovery (CRi) and reductions in bone marrow blasts in 5 of 6 of the evaluable FLT3 mutated patients