5.05Open5.05Pre Close0 Volume4.12K Open Interest10.00Strike Price0.00Turnover825.17%IV12.23%PremiumDec 20, 2024Expiry Date4.36Intrinsic Value100Multiplier5DDays to Expiry0.69Extrinsic Value100Contract SizeAmericanOptions Type-0.5374Delta0.0719Gamma1.02Leverage Ratio-0.2221Theta-0.0011Rho-0.55Eff Leverage0.0027Vega
Trytosaveabit OP : Preliminary data supports BMF-500's potential as a transformative therapy for patients with FLT3 mutated relapsed or refractory (R/R) acute leukemia
BMF-500 showed a favorable safety and tolerability profile, with no dose-limiting toxicities observed across all dose levels
Pharmacokinetic and pharmacodynamic data confirmed on-target FMS-like tyrosine kinase 3 (FLT3) inhibition, demonstrating dose-proportional activity and good compartmental penetration
Preliminary Phase I data for BMF-500 in R/R acute leukemia patients with FLT3 gene mutations having failed gilteritinib indicated clinical activity with evidence of responses, including a first complete response with incomplete hematologic recovery (CRi) and reductions in bone marrow blasts in 5 of 6 of the evaluable FLT3 mutated patients