Here are the top gap ups and downs for the stocks with a market cap above $5 billion after the previous market closed (gaps range from large to small):
Gap Ups
1. $Oak Street Health (OSH.US)$ -up 26.6%
2. $Baidu (BIDU.US)$ -up 7.5%
3. $BP PLC (BP.US)$ -up 3.2%
4. $Fiserv (FISV.US)$ -up 2.4%
5. $Mitsubishi UFJ Financial Group (MUFG.US)$ -up 1.4%
6. $GlaxoSmithKline (GSK.US)$ -up 0.8%
7. $Microsoft (MSFT.US)$ -up 0.7%
8. $Sanofi (SNY.US)$ -up 0.5%
9. $Activision Blizzard (ATVI.US)$ -up 0.4%...

Gapping up
In reaction to earnings/guidance:
• $New Relic (NEWR.US)$ +3.8% (guidance), $American Airlines (AAL.US)$ +2% (guidance)
Other news:
• $DICE THERAPEUTICS, INC. (DICE.US)$ +66.5% (announces "positive" topline data from its Phase 1 clinical trial of DC-806 an oral small molecule antagonist of the pro-inflammatory cytokine IL-17)
• $Albireo Pharma (ALBO.US)$ +17.2% (reports positive topline data from Phase 3 Trial of Bylvay (odevix...

Upgrades
• $Coupang (CPNG.US)$ : Credit Suisse Upgrades to Outperform from Neutral - PT $19 (from $28)
• $First Republic Bank (FRC.US)$ : Atlantic Equities Upgrades to Overweight from Neutral - PT $188 (from $210)
• $Sitio Royalties (STR.US)$ : RBC Capital Upgrades to Outperform from Sector Perform - PT $43 (from $36)
Downgrades
• $Duck Creek Technologies (DCT.US)$ : JMP Securities Downgrades to Market Perform from Market Outperform
•...

Gainers:
• $La-Z-Boy (LZB.US)$ +9.3% (In reaction to earnings/guidance)
• $Enanta Pharmaceuticals (ENTA.US)$ +6.7% (ENTA files patent infringement lawsuit against $Pfizer (PFE.US)$)
• $Ikena Oncology (IKNA.US)$ +6.6% (granted Fast Track designation for IK-930)
• $BridgeBio Pharma (BBIO.US)$ +6.4% (Announces Early Positive Data for BBP-812)
• $Krystal Biotech (KRYS.US)$ +5% (submits Biologies License Application to FDA seeking approval of B-V...